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GPCR

NameGlucagon receptor
SpeciesHomo sapiens (Human)
GeneGCGR
SynonymGL-R
GGR
GR
glucagon receptor
DiseaseDiabetes
Type 2 diabetes
Non-insulin dependent diabetes
Obesity; Diabetes
Type 1 diabetes
[ Show all ]
Length477
Amino acid sequenceMPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProtP47871
Protein Data Bank5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod modelP47871
3D structure modelThis structure is from PDB ID 5yqz.
BioLiPBL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target DatabaseT60182, T87875
ChEMBLCHEMBL1985
IUPHAR251
DrugBankN/A

Ligand

NameCHEMBL416559
Molecular formulaC24H35NO
IUPAC name[4-(3-methylphenyl)-5-pentyl-2,6-di(propan-2-yl)pyridin-3-yl]methanol
Molecular weight353.55
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP6.7
Synonyms2,6-Diisopropyl-4-(3-methylphenyl)-5-pentylpyridine-3-methanol
BPQDRDSDQFNWOU-UHFFFAOYSA-N
SCHEMBL2649458
2,6-Diisopropyl-3-hydroxymethyl-4-(3-methylphenyl)-5-pentylpyridine
Inchi KeyBPQDRDSDQFNWOU-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H35NO/c1-7-8-9-13-20-22(19-12-10-11-18(6)14-19)21(15-26)24(17(4)5)25-23(20)16(2)3/h10-12,14,16-17,26H,7-9,13,15H2,1-6H3
PubChem CID22005070
ChEMBLCHEMBL416559
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition46.0 %PMID11965376ChEMBL

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