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Name | Sphingosine 1-phosphate receptor 4 |
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Species | Homo sapiens (Human) |
Gene | S1PR4 |
Synonym | S1P4 receptor S1P4 S1P receptor Edg-6 S1P receptor 4 endothelial differentiation, G protein-coupled receptor 6 [ Show all ] |
Disease | N/A |
Length | 384 |
Amino acid sequence | MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI |
UniProt | O95977 |
Protein Data Bank | N/A |
GPCR-HGmod model | O95977 |
3D structure model | This predicted structure model is from GPCR-EXP O95977. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3230 |
IUPHAR | 278 |
DrugBank | N/A |
Name | CHEMBL515603 |
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Molecular formula | C22H23N2O6P |
IUPAC name | [(2S)-2-amino-2-methyl-3-oxo-3-[4-(4-phenylphenoxy)anilino]propyl] dihydrogen phosphate |
Molecular weight | 442.408 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 4 |
XlogP | -0.5 |
Synonyms | BDBM50249238 SCHEMBL14263186 (S)-2-amino-3-(4-(biphenyl-4-yloxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphate |
Inchi Key | BPFTXGAARBAJDP-QFIPXVFZSA-N |
Inchi ID | InChI=1S/C22H23N2O6P/c1-22(23,15-29-31(26,27)28)21(25)24-18-9-13-20(14-10-18)30-19-11-7-17(8-12-19)16-5-3-2-4-6-16/h2-14H,15,23H2,1H3,(H,24,25)(H2,26,27,28)/t22-/m0/s1 |
PubChem CID | 11690779 |
ChEMBL | CHEMBL515603 |
IUPHAR | N/A |
BindingDB | 50249238 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 123.0 nM | PMID19282175 | BindingDB,ChEMBL |
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