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GPCR

Name5-hydroxytryptamine receptor 1D
SpeciesSus scrofa (Pig)
GeneHTR1D
Synonym5-HT-1D
5-HT1D
Serotonin receptor 1D
DiseaseN/A for non-human GPCRs
Length291
Amino acid sequenceAMTDLLVSILVMPISIPYTITQTWSFGQLLCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAIVWAISICISIPPLFWRQARAHEEISDCLVNTSQISYTIYSTCGAFYIPSLLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNPSLHEGHSHSAGSPLFFNHVKIKLADSVLERKRISAARERKATKTLGIILGAFIICWLPFFVASLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKVV
UniProtP79400
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4105
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL320412
Molecular formulaC17H26N4O2S
IUPAC name2-[5-[(4,4-dimethyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl)methyl]-1H-indol-3-yl]-N,N-dimethylethanamine
Molecular weight350.481
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP1.6
SynonymsBDBM50422026
SCHEMBL8808054
2-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-4,4-dimethyl-1,2,5-thiadiazolidine 1,1-dioxide
Inchi KeyBOFZPIYNCDADLB-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H26N4O2S/c1-17(2)12-21(24(22,23)19-17)11-13-5-6-16-15(9-13)14(10-18-16)7-8-20(3)4/h5-6,9-10,18-19H,7-8,11-12H2,1-4H3
PubChem CID10337965
ChEMBLCHEMBL320412
IUPHARN/A
BindingDB50422026
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50100.0 nMPMID7932524BindingDB,ChEMBL

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