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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Gallus gallus (Chicken)
Gene	CHRM4
Synonym	N/A
Disease	N/A for non-human GPCRs
Length	490
Amino acid sequence	MHNLSAQPWQAKMANLTYDNVTLSNRSEVAIQPPTNYKTVELVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGVFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWILSFILWAPAILFWQFIVGKRTVHERECYIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVRRHKPESRKERKGKSLSFFKAPPVKQNNNNSPKRAVEVKEEVRNGKVDDQPSAQTEATGQQEEKETSNESSTVSMTQTTKDKPTTEILPAGQGQSPAHPRVNPTSKWSKIKIVTKQTGTESVTAIEIVPAKAGASDHNSLSNSRPANVARKFASIARSQVRKKRQMAAREKKVTRTIFAILLAFILTWTPYNVMVLINTFCETCVPETVWSIGYWLCYVNSTINPACYALCNATFKKTFKHLLMCQYRNIGTAR
UniProt	P17200
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	eucatropine
Molecular formula	C17H25NO3
IUPAC name	(1,2,2,6-tetramethylpiperidin-4-yl) 2-hydroxy-2-phenylacetate
Molecular weight	291.391
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.8
Synonyms	Prestwick0_000794 (1,2,2,6-tetramethylpiperidin-4-yl) 2-hydroxy-2-phenylacetate AC1L1OZA CHEBI:94371 Eucatropinum Prestwick3_000794 1,2,2,6-tetramethylpiperidin-4-yl 2-hydroxy-2-phenylacetate Benzeneacetic acid, .alpha.-hydroxy-, 1,2,2,6-tetramethyl-4-piperidinyl ester EINECS 202-900-0 FT-0712100 SPBio_002867 4SPJ105W8E BSPBio_000928 NCGC00179372-01 Prestwick1_000794 1,2,2,6-Tetramethyl-4-piperidinyl hydroxy(phenyl)acetate # AC1Q60W7 CHEMBL1618660 Eucatropinum [INN-Latin] QSAVEGSLJISCDF-UHFFFAOYSA-N 100-91-4 BPBio1_001022 Eucatropina L000976 NSC_7534 UNII-4SPJ105W8E CAS_100-91-4 Eucatropine [INN:BAN] Prestwick2_000794 1,2,2,6-Tetramethyl-4-piperidyl mandelate BDBM82377 DTXSID1048465 Euphthalmine SCHEMBL132347 2-hydroxy-2-phenylacetic acid (1,2,2,6-tetramethyl-4-piperidinyl) ester BRD-A37942872-003-03-2 Eucatropina [INN-Spanish] n-methyl-b-vinyldiacetonaikamine mandelate [ Show all ]
Inchi Key	QSAVEGSLJISCDF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H25NO3/c1-12-10-14(11-17(2,3)18(12)4)21-16(20)15(19)13-8-6-5-7-9-13/h5-9,12,14-15,19H,10-11H2,1-4H3
PubChem CID	7534
ChEMBL	N/A
IUPHAR	N/A
BindingDB	82377
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	426.58 nM	PMID2250662	BindingDB

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