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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Rattus norvegicus (Rat)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P08482
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL276
IUPHAR	13
DrugBank	N/A

Ligand

Name	eucatropine
Molecular formula	C17H25NO3
IUPAC name	(1,2,2,6-tetramethylpiperidin-4-yl) 2-hydroxy-2-phenylacetate
Molecular weight	291.391
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.8
Synonyms	QSAVEGSLJISCDF-UHFFFAOYSA-N 100-91-4 BPBio1_001022 Eucatropina L000976 UNII-4SPJ105W8E CAS_100-91-4 Eucatropine [INN:BAN] NSC_7534 1,2,2,6-Tetramethyl-4-piperidyl mandelate BDBM82377 DTXSID1048465 Euphthalmine Prestwick2_000794 SCHEMBL132347 2-hydroxy-2-phenylacetic acid (1,2,2,6-tetramethyl-4-piperidinyl) ester BRD-A37942872-003-03-2 Eucatropina [INN-Spanish] n-methyl-b-vinyldiacetonaikamine mandelate (1,2,2,6-tetramethylpiperidin-4-yl) 2-hydroxy-2-phenylacetate AC1L1OZA CHEBI:94371 Eucatropinum Prestwick0_000794 1,2,2,6-tetramethylpiperidin-4-yl 2-hydroxy-2-phenylacetate Benzeneacetic acid, .alpha.-hydroxy-, 1,2,2,6-tetramethyl-4-piperidinyl ester EINECS 202-900-0 FT-0712100 Prestwick3_000794 SPBio_002867 4SPJ105W8E BSPBio_000928 NCGC00179372-01 1,2,2,6-Tetramethyl-4-piperidinyl hydroxy(phenyl)acetate # AC1Q60W7 CHEMBL1618660 Eucatropinum [INN-Latin] Prestwick1_000794 [ Show all ]
Inchi Key	QSAVEGSLJISCDF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H25NO3/c1-12-10-14(11-17(2,3)18(12)4)21-16(20)15(19)13-8-6-5-7-9-13/h5-9,12,14-15,19H,10-11H2,1-4H3
PubChem CID	7534
ChEMBL	N/A
IUPHAR	N/A
BindingDB	82377
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	91.2 nM	PMID2250662	BindingDB

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