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GPCR

NameProstaglandin E2 receptor EP4 subtype
SpeciesHomo sapiens (Human)
GenePTGER4
SynonymProstanoid EP4 receptor
PGE2 receptor EP4 subtype
PGE receptor EP4 subtype
EP4 receptor
EP2
DiseaseUlcerative colitis
Glaucoma
Inflammatory disease
Migraine
Osteoarthritis
[ Show all ]
Length488
Amino acid sequenceMSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
UniProtP35408
Protein Data Bank5ywy, 5yhl
GPCR-HGmod modelP35408
3D structure modelThis structure is from PDB ID 5ywy.
BioLiPBL0434347, BL0434289
Therapeutic Target DatabaseT18876
ChEMBLCHEMBL1836
IUPHAR343
DrugBankBE0003522

Ligand

NameCHEMBL1080281
Molecular formulaC24H15Cl2F3N4O3S
IUPAC nameN-[5-[1-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methylindol-7-yl]-1,3,4-oxadiazol-2-yl]-3,4-difluorobenzenesulfonamide
Molecular weight567.364
Hydrogen bond acceptor9
Hydrogen bond donor1
XlogP5.9
SynonymsSCHEMBL1925701
BDBM50311625
N-(5-(1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl)-1,3,4-oxadiazol-2-yl)-3,4-difluorobenzenesulfonamide
Inchi KeyBNWORVIARAMAHR-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H15Cl2F3N4O3S/c1-12-10-33(11-13-2-3-14(25)6-19(13)26)22-17(12)7-15(27)8-18(22)23-30-31-24(36-23)32-37(34,35)16-4-5-20(28)21(29)9-16/h2-10H,11H2,1H3,(H,31,32)
PubChem CID46879896
ChEMBLCHEMBL1080281
IUPHARN/A
BindingDB50311625
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity13.0 %PMID19836233ChEMBL
Activity26.0 %PMID19836233ChEMBL
Activity32.0 %PMID19836233ChEMBL

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