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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Type-2 angiotensin II receptor
Species	Rattus norvegicus (Rat)
Gene	Agtr2
Synonym	angiotensin II receptor, type 2 MRX88 Agtr2 AT2R AT2-R AT2 receptor angiotensin II receptor angiotensin receptor 2 Angiotensin II type-2 receptor angiotensin II type 2 receptor AT2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	363
Amino acid sequence	MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
UniProt	P35351
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL257
IUPHAR	35
DrugBank	N/A

Ligand

Name	CHEMBL97075
Molecular formula	C33H28F6N4O5S
IUPAC name	N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-5-methyl-2-(trifluoromethyl)furan-3-carboxamide
Molecular weight	706.66
Hydrogen bond acceptor	12
Hydrogen bond donor	1
XlogP	7.3
Synonyms	SCHEMBL9566052 4''-[3-Butyl-5-oxo-1-(2-trifluoromethyl-phenyl)-1,5-dihydro-[1,2,4]triazol-4-ylmethyl]-biphenyl-2-sulfonic acid (5-methyl-2-trifluoromethyl-furan-3-carbonyl)-amide BDBM50039882
Inchi Key	BNFFMFZFKZQWDG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C33H28F6N4O5S/c1-3-4-13-28-40-43(26-11-7-6-10-25(26)32(34,35)36)31(45)42(28)19-21-14-16-22(17-15-21)23-9-5-8-12-27(23)49(46,47)41-30(44)24-18-20(2)48-29(24)33(37,38)39/h5-12,14-18H,3-4,13,19H2,1-2H3,(H,41,44)
PubChem CID	10417351
ChEMBL	CHEMBL97075
IUPHAR	N/A
BindingDB	50039882
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	60.0 nM	PMID8064808	BindingDB,ChEMBL

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