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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Adenosine receptor A2b
Species	Rattus norvegicus (Rat)
Gene	Adora2b
Synonym	A2b A2B receptor A2BR adenosine receptor A2b
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAITISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGTRARGIIAVLWVLAFGIGLTPFLGWNSKDRATSNCTEPGDGITNKSCCPVKCLFENVVPMSYMVYFNFFGCVLPPLLIMMVIYIKIFMVACKQLQHMELMEHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAINCITLFHPALAKDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFRYSFHRIISRYVLCQTDTKGGSGQAGGQSTFSLSL
UniProt	P29276
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2592
IUPHAR	20
DrugBank	N/A

Ligand

Name	CHEMBL307105
Molecular formula	C19H23ClN4O2
IUPAC name	7-(2-chloroethyl)-8-phenyl-1,3-dipropylpurine-2,6-dione
Molecular weight	374.869
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.5
Synonyms	7-(2-Chloro-ethyl)-8-phenyl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione BDBM50113239
Inchi Key	QITWXKORLMEMBF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H23ClN4O2/c1-3-11-23-17-15(18(25)24(12-4-2)19(23)26)22(13-10-20)16(21-17)14-8-6-5-7-9-14/h5-9H,3-4,10-13H2,1-2H3
PubChem CID	10861697
ChEMBL	CHEMBL307105
IUPHAR	N/A
BindingDB	50113239
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3360.0 nM	PMID12014951	BindingDB,ChEMBL

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