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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Mus musculus (Mouse)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P12657
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3733
IUPHAR	13
DrugBank	N/A

Ligand

Name	pilocarpine
Molecular formula	C11H16N2O2
IUPAC name	(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
Molecular weight	208.261
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	1.1
Synonyms	Syncarpine Miocarpine (TN) 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)- NCGC00023339-12 AB00053525-27 Ocusert AKOS016010311 Pilocarpin BPBio1_000548 Pilocarpine [USAN:BAN:JAN] CHEBI:8207 Piloptic-1 DivK1c_000358 Prestwick1_000449 HMS2089K17 Scheinpharm (TN) KB-207616 Lopac0_000950 (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one Tox21_110887 Spectrum5_001379 (3S-cis)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone NCGC00023339-07 3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one NCGC00023339-16 AC1L1LEF Ocusert pilo-20 AN-42585 Pilocarpine (TN) BSPBio_000498 Pilocarpine-d3 HCl (deuterated) D00525 Piloptic-3 DSSTox_RID_75984 QCHFTSOMWOSFHM-WPRPVWTQSA-N Imidazole-5-butyric acid, alpha-ethyl-beta-(hydroxymethyl)-1-methyl-, gamma-lactone SPBio_001287 KBio2_004155 (+)-Pilocarpine LS-7661 ZINC75008 SR-01000075339-11 Minims Pilocarpine 092P137 NCGC00023339-10 91484-73-0 NSC5746 AK116461 P.V. Carpine Liquifilm beta-Pilocarpine hydrochloride Pilocarpine Mononitrate, (3S-cis)-Isomer CAS-92-13-7 Pilokarpol DB01085 Pilostat Epicar SBB012409 Isopto carpine (TN) KBioGR_000956 (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]oxolan-2-one Spectrum3_000546 Timpilo (TN) (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]tetrahydrofuran-2-one NCGC00023339-03 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S,4R)- NCGC00023339-13 AB00053525_28 Ocusert P 20 Almocarpine BRD-K85090592-008-05-2 Pilocarpine [USP:BAN:JAN] Piloptic-1/2 DSSTox_CID_1162 Prestwick2_000449 HSDB 3163 SCHEMBL15146 KBio1_000358 Lopac0_000960 Tox21_110887_1 Spectrum_001107 (3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone NCGC00023339-08 NCI60_004403 Adsorbocarpine Ocusert pilo-20 (TN) AX8148055 Pilocarpine chloride BSPBio_002191 Pilocarpol D06HLY Piloptic-4 DTXSID1021162 Salagen isopilocarpine SPBio_002437 KBio2_006723 (3S,4R)-3-Ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one MCULE-2634151840 ST069319 Miocarpine 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S,4R)- NCGC00023339-11 92-13-7 Ocu-Carpine Akarpine Pilagan BIDD:GT0217 Pilocarpine nitrate salt CCG-205031 Pilopine HS (TN) Diocarpine (TN) Prestwick0_000449 GTPL305 SBI-0050924.P004 Isoptocarpine KBioSS_001587 (3S,4R)-3-ethyl-4-[(1-methylimidazol-5-yl)methyl]-3,4,5-trihydrofuran-2-one Spectrum4_000478 Tocris-0694 (3S,4R)-3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone NCGC00023339-06 3-Ethyl-4-(3-methyl-3H-imidazol-4-ylmethyl)dihydrofuran-2-one NCGC00023339-14 AB00053525_29 Ocusert pilo Amistura P Pilocarpine (JAN/USP) BRD-K85090592-008-15-1 Pilocarpine, Monohydrochloride, (3S-cis)-Isomer CHEMBL550 Piloptic-2 DSSTox_GSID_21162 Prestwick3_000449 IDI1_000358 SDCCGMLS-0003164.P005 KBio2_001587 LS-187208 UNII-01MI4Q9DI3 Spersacarpine Mi-Pilo 01MI4Q9DI3 NCGC00023339-09 NINDS_000358 AI3-50523 Ocusert Pilo-40 BDBM50008072 Pilocarpine monohydrochloride C07474 Pilokarpin Piloptic-6 EINECS 202-128-4 Salagen (TN) Isopto carpine Spectrum2_001284 KBio3_001691 (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one [ Show all ]
Inchi Key	QCHFTSOMWOSFHM-WPRPVWTQSA-N
Inchi ID	InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1
PubChem CID	5910
ChEMBL	CHEMBL550
IUPHAR	305
BindingDB	50008072
DrugBank	DB01085
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	6900.0 nM	PMID9111297	BindingDB,ChEMBL
Smax	150.0 %	PMID9111297	ChEMBL

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