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GPCR

Name	Prostaglandin E2 receptor EP1 subtype
Species	Homo sapiens (Human)
Gene	PTGER1
Synonym	PGE receptor EP1 subtype EP1 receptor prostaglandin E receptor 1 (subtype EP1), 42kDa Prostanoid EP1 receptor EP1 prostanoid receptor PGE2 receptor EP1 subtype [ Show all ]
Disease	Unspecified Thrombosis Pollakiuria Pain
Length	402
Amino acid sequence	MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
UniProt	P34995
Protein Data Bank	N/A
GPCR-HGmod model	P34995
3D structure model	This predicted structure model is from GPCR-EXP P34995.
BioLiP	N/A
Therapeutic Target Database	T15497
ChEMBL	CHEMBL1811
IUPHAR	340
DrugBank	BE0000064

Ligand

Name	dinoprost
Molecular formula	C20H34O5
IUPAC name	(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid
Molecular weight	354.487
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	2.7
Synonyms	HMS2089F11 (5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid LMFA03010002 (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(E)-(3S)-3-hydroxy-1-octenyl}-cyclopentyl]-5-heptenoic acid P1885 PGF2.alpha. 9a,11a-PGF2 Prostaglandin F2 B7IN85G1HY Prostaglandin F2\|A CAS-551-11-1 SR-01000721847 CS-4232 U-14583 Dinoprost [USAN:INN:BAN:JAN] DSSTox_RID_76800 HSDB 3315 (5Z,9alpha,11alpha,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoate NCGC00160385-01 23518-25-4 PGF-2alpha 7-(3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoic acid Prosmon (TN) 9S,11R,15S-trihydroxy-5Z,13E-prostadienoic acid Prostaglandin F2-alpha, racemic mixt. BRN 2225571 Prostin F2-alpha Cerviprost SR-01000946457 D00HTY ZINC3830709 Dinoprostum Enzaprost F (+)-Prostaglandin F2a (+-)-PGF2alpha l-PGF2-alpha (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoic acid NCGC00160385-05 5-HEPTENOIC ACID, 7-(3,5-DIHYDROXY-2-(3-HYDROXY-1-OCTENYL)CYCLOPENTYL)-, dl- PGF2-alpha 9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9alpha,11alpha,13E,15S)- amoglandin prostaglandin F2alpha C00639 PXGPLTODNUVGFL-YNNPMVKQSA-N CHEMBL815 U 14583 DSSTox_CID_2946 HMS1791K16 HMS3402K16 (5Z,9alpha,11alpha,13E,15S)-9,11,15-Trihydroxyprosta-3,13-dien-1-oic acid LS-125835 13535-33-6 panacelan 551-11-1 PGF2a 9alpha,11alpha-PGF2 Prostaglandin F2 alpha BDBM50035622 Prostarmon F CCG-208257 SR-01000721847-2 cyclosin UNII-B7IN85G1HY Dinoprosta DTXSID9022946 HY-12956 (5z,9alpha,11alpha,13e,15s)-9,11,15-trihydroxyprosta-5,13-dienoic acid NCGC00160385-02 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-, (+-)- PGF2 7-[3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-5-heptenoic acid Prosta-10,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9.alpha.,11.alpha.,13E,15S) AC1NQWY5 Prostaglandin F2.alpha. BRN 4153898 Prostin F2alpha CHEBI:15553 SR-01000946457-1 Dinoprostum [INN-Latin] GTPL1884 (+)-Prostaglandin F2alpha (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate l-Prostaglandin F2-alpha (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid NCGC00160385-06 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-, l- PGF2-alpha racemic mixt. 99437-94-2 Prostaglandin F(sub 2a) AN-796 Prostaglandin F2alpha, dl- C20H34O5 SCHEMBL24292 CP0104 U-14,583 Dinoprost (JP17/USAN/INN) DSSTox_GSID_22946 HMS1989K16 HMS3648N11 (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid MolPort-005-940-967 PDSP2_000079 62P015 PGF2alpha 9alpha,11beta-PGF2 Prostaglandin F2-alpha BML1-F08 Prostin F 2 alpha CCRIS 4253 SR-01000721847-4 D00081 Y0222 Dinoprosta [INN-Spanish] Enzaprost ( )-Prostaglandin F2alpha (+-)-PGF2-alpha IDI1_033964 (E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid NCGC00160385-04 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-, (1R-(1alpha(Z),2beta(S*,E),3alpha,5alpha))- PGF2 alpha 9,11,15-Trihydroxy-(5Z,9a,11a,13E,15S)-prosta-5,13-dien-1-oic acid Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9-alpha,11-alpha,13E,15S)-(+-)- (9CI) AKOS030526160 Prostaglandin F2a BSPBio_001494 Protamodin Tox21_111777 DB12789 dl-Prostaglandin F2-alpha HMS1361K16 [ Show all ]
Inchi Key	PXGPLTODNUVGFL-YNNPMVKQSA-N
Inchi ID	InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
PubChem CID	5280363
ChEMBL	CHEMBL815
IUPHAR	1884
BindingDB	50035622
DrugBank	DB12789
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	600.0 nM	PMID10915040	BindingDB,ChEMBL
IC50	220.0 nM	PMID11708917	BindingDB,ChEMBL
IC50	380.0 nM	PMID10715159	BindingDB,ChEMBL
Ki	501.187 - 630.957 nM	PMID10634944, PMID11999132	IUPHAR

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