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GPCR

NameGlucagon receptor
SpeciesHomo sapiens (Human)
GeneGCGR
SynonymGL-R
GGR
GR
glucagon receptor
DiseaseDiabetes
Type 2 diabetes
Non-insulin dependent diabetes
Obesity; Diabetes
Type 1 diabetes
[ Show all ]
Length477
Amino acid sequenceMPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProtP47871
Protein Data Bank5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod modelP47871
3D structure modelThis structure is from PDB ID 5yqz.
BioLiPBL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target DatabaseT60182, T87875
ChEMBLCHEMBL1985
IUPHAR251
DrugBankN/A

Ligand

NameCHEMBL154400
Molecular formulaC27H28ClN3O3
IUPAC name3-chloro-N-[(E)-[4-[2-(2-ethylpiperidin-1-yl)-2-oxoethyl]naphthalen-1-yl]methylideneamino]-4-hydroxybenzamide
Molecular weight477.989
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP5.6
Synonyms3-Chloro-4-hydroxy-benzoic acid {4-[2-(2-ethyl-piperidin-1-yl)-2-oxo-ethyl]-naphthalen-1-ylmethylene}-hydrazide
BDBM50122146
SCHEMBL2664111
Inchi KeyBLTGLSZGVUVZAS-STBIYBPSSA-N
Inchi IDInChI=1S/C27H28ClN3O3/c1-2-21-7-5-6-14-31(21)26(33)16-18-10-11-20(23-9-4-3-8-22(18)23)17-29-30-27(34)19-12-13-25(32)24(28)15-19/h3-4,8-13,15,17,21,32H,2,5-7,14,16H2,1H3,(H,30,34)/b29-17+
PubChem CID11826907
ChEMBLCHEMBL154400
IUPHARN/A
BindingDB50122146
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC507.4 nMPMID12477359BindingDB,ChEMBL

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