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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Sphingosine 1-phosphate receptor 2
Species	Homo sapiens (Human)
Gene	S1PR2
Synonym	Endothelial differentiation G-protein coupled receptor 5 Sphingosine 1-phosphate receptor Edg-5 S1P2 receptor S1P2 S1P receptor Edg-5 S1P receptor 2 edg5 endothelial differentiation G protein-coupled receptor 5 GPCR18 Gpcr13 G protein-coupled receptor 13 [ Show all ]
Disease	Hypertension
Length	353
Amino acid sequence	MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
UniProt	O95136
Protein Data Bank	N/A
GPCR-HGmod model	O95136
3D structure model	This predicted structure model is from GPCR-EXP O95136.
BioLiP	N/A
Therapeutic Target Database	T47888
ChEMBL	CHEMBL2955
IUPHAR	276
DrugBank	N/A

Ligand

Name	CHEMBL117403
Molecular formula	C18H30NO5P
IUPAC name	3-[(4-heptoxycarbonylphenyl)methylamino]propylphosphonic acid
Molecular weight	371.414
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	0.3
Synonyms	BDBM50148422 SCHEMBL14195650 4-[(3-Phosphono-propylamino)-methyl]-benzoic acid heptyl ester
Inchi Key	POPQMXAKAVJFNJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H30NO5P/c1-2-3-4-5-6-13-24-18(20)17-10-8-16(9-11-17)15-19-12-7-14-25(21,22)23/h8-11,19H,2-7,12-15H2,1H3,(H2,21,22,23)
PubChem CID	10215741
ChEMBL	CHEMBL117403
IUPHAR	N/A
BindingDB	50148422
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<10000.0 nM	PMID15177461	BindingDB,ChEMBL
IC50	680.0 nM	PMID15177461	BindingDB,ChEMBL

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