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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Rattus norvegicus (Rat)
Gene	Htr1a
Synonym	5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A ADRB2RL1 ADRBRL1 5-HT-1A Gpcr18 Serotonin receptor 1A [ Show all ]
Disease	N/A for non-human GPCRs
Length	422
Amino acid sequence	MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProt	P19327
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL273
IUPHAR	1
DrugBank	N/A

Ligand

Name	CP 93129
Molecular formula	C12H13N3O
IUPAC name	3-(1,2,3,6-tetrahydropyridin-4-yl)-1,4-dihydropyrrolo[3,2-b]pyridin-5-one
Molecular weight	215.256
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	-0.1
Synonyms	CAS_127792-75-0 D00FHZ SCHEMBL781544 3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one CHEMBL304008 L000200 ZINC4439 127792-75-0 879089-64-2 BDBM84737 CP-93129 PDSP1_000796 3-(1,2,3,6-tetrahydropyridin-4-yl)-1,4-dihydropyrrolo[2,3-e]pyridin-5-one CHEBI:93436 DTXSID50155670 SCHEMBL9696192 1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrolo[3,2-b]pyridin-5-one Hydrochloride Hydrate 5-hydroxy-3(4-1,2,5,6-tetrahydropyridyl)-4-azaindole LS-184387 3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1,4-dihydro-pyrrolo[3,2-b]pyridin-5-one AB07658 BRD-K81876028-300-01-2 CP93129 PDSP2_000784 3-(1,2,3,6-tetrahydropyridin-4-yl)-1,4-dihydropyrrolo[3,2-b]pyridin-5-one GTPL11 Tocris-1032 5H-Pyrrolo(3,2-b)pyridin-5-one, 1,4-dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)- AC1L3XQ4 CP-93,129 NCGC00024952-01 3-(1,2,3,6-tetrahydropyridin-4-yl)-1,4-dihydro-5H-pyrrolo[3,2-b]pyridin-5-one [ Show all ]
Inchi Key	PJYVGMRFPFNZCT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H13N3O/c16-11-2-1-10-12(15-11)9(7-14-10)8-3-5-13-6-4-8/h1-3,7,13-14H,4-6H2,(H,15,16)
PubChem CID	124007
ChEMBL	CHEMBL304008
IUPHAR	11
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3000.0 nM	PMID2374139	ChEMBL

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