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GLASS

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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL88045
Molecular formula	C22H18FN3S
IUPAC name	4-[5-(4-fluorophenyl)-3-methyl-2-(4-methylsulfanylphenyl)imidazol-4-yl]pyridine
Molecular weight	375.465
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.5
Synonyms	BDBM50104381 SCHEMBL7229394 4-[5-(4-Fluoro-phenyl)-3-methyl-2-(4-methylsulfanyl-phenyl)-3H-imidazol-4-yl]-pyridine
Inchi Key	BJXGEYDZUISYLS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H18FN3S/c1-26-21(16-11-13-24-14-12-16)20(15-3-7-18(23)8-4-15)25-22(26)17-5-9-19(27-2)10-6-17/h3-14H,1-2H3
PubChem CID	20674619
ChEMBL	CHEMBL88045
IUPHAR	N/A
BindingDB	50104381
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	521.0 nM	N/A	BindingDB
IC50	521.19 nM	Med Chem Res, (2013) None:None:1	ChEMBL
Inhibition	10.0 %	PMID11549467	ChEMBL

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