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GPCR

NameG-protein coupled receptor 35
SpeciesHomo sapiens (Human)
GeneGPR35
SynonymG-protein coupled receptor 3
GPR35
KYNA receptor
Kynurenic acid receptor
DiseaseN/A
Length309
Amino acid sequenceMNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProtQ9HC97
Protein Data BankN/A
GPCR-HGmod modelQ9HC97
3D structure modelThis predicted structure model is from GPCR-EXP Q9HC97.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293267
IUPHAR102
DrugBankBE0005562

Ligand

NameCHEMBL2431112
Molecular formulaC21H24N4O3
IUPAC name6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
Molecular weight380.448
Hydrogen bond acceptor7
Hydrogen bond donor0
XlogP3.5
SynonymsMolPort-008-341-882
BDBM50440780
MCULE-6262182369
6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
STK940146
[ Show all ]
Inchi KeyOTRKBWNAVFQFNL-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H24N4O3/c1-26-18-7-5-4-6-17(18)24-8-10-25(11-9-24)21-15-12-19(27-2)20(28-3)13-16(15)22-14-23-21/h4-7,12-14H,8-11H2,1-3H3
PubChem CID10339735
ChEMBLCHEMBL2431112
IUPHARN/A
BindingDB50440780
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<40000.0 nMPMID24611085BindingDB,ChEMBL

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