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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesMus musculus (Mouse)
GeneMchr1
SynonymSLC-1 {ECO:0000303|PubMed:11159839}
MCHR-1
MCHR
MCH1R
MCH1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length353
Amino acid sequenceMDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProtQ8JZL2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4730
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL425744
Molecular formulaC27H29N5O2
IUPAC name1-(4-phenylmethoxyphenyl)-3-[1-(2-pyrrolidin-1-ylethyl)indazol-4-yl]urea
Molecular weight455.562
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP4.1
Synonyms1-(4-Benzyloxy-phenyl)-3-[1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-4-yl]-urea
BDBM50167572
Inchi KeyOQQPXDHOWXVXAA-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H29N5O2/c33-27(29-22-11-13-23(14-12-22)34-20-21-7-2-1-3-8-21)30-25-9-6-10-26-24(25)19-28-32(26)18-17-31-15-4-5-16-31/h1-3,6-14,19H,4-5,15-18,20H2,(H2,29,30,33)
PubChem CID44402535
ChEMBLCHEMBL425744
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501053.0 nMPMID15911251ChEMBL

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