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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	CHEMBL239733
Molecular formula	C24H27Cl2N3O
IUPAC name	N-[5-[4-(2,3-dichlorophenyl)piperazin-1-yl]pentyl]-3-ethynylbenzamide
Molecular weight	444.4
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.4
Synonyms	BDBM50221676 N-(5-(4-(2,3-dichlorophenyl)piperazin-1-yl)pentyl)-3-ethynylbenzamide
Inchi Key	BHVASJSYMURYLK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H27Cl2N3O/c1-2-19-8-6-9-20(18-19)24(30)27-12-4-3-5-13-28-14-16-29(17-15-28)22-11-7-10-21(25)23(22)26/h1,6-11,18H,3-5,12-17H2,(H,27,30)
PubChem CID	44436621
ChEMBL	CHEMBL239733
IUPHAR	N/A
BindingDB	50221676
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Activity	80.0 %	PMID17827018	ChEMBL
Ki	5.6 nM	PMID17827018	BindingDB,ChEMBL

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