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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Gallus gallus (Chicken)
Gene	CHRM4
Synonym	N/A
Disease	N/A for non-human GPCRs
Length	490
Amino acid sequence	MHNLSAQPWQAKMANLTYDNVTLSNRSEVAIQPPTNYKTVELVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGVFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWILSFILWAPAILFWQFIVGKRTVHERECYIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVRRHKPESRKERKGKSLSFFKAPPVKQNNNNSPKRAVEVKEEVRNGKVDDQPSAQTEATGQQEEKETSNESSTVSMTQTTKDKPTTEILPAGQGQSPAHPRVNPTSKWSKIKIVTKQTGTESVTAIEIVPAKAGASDHNSLSNSRPANVARKFASIARSQVRKKRQMAAREKKVTRTIFAILLAFILTWTPYNVMVLINTFCETCVPETVWSIGYWLCYVNSTINPACYALCNATFKKTFKHLLMCQYRNIGTAR
UniProt	P17200
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	ipratropium
Molecular formula	C20H30NO3+
IUPAC name	(8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate
Molecular weight	332.464
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.6
Synonyms	Prestwick2_000575 SCHEMBL3124 [(5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate AB01274716-01 Apovent (TN) BDBM82372 D0S0AS Ipraxa Narilet Rinatec Vagos AC1Q6241 Atrovent Aerosol CAS_22254-24-6 HMS3259E14 L000784 NCGC00022819-02 Prestwick0_000575 SCHEMBL12055829 [(1R,5S)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] (2R)-3-hydroxy-2-phenylpropanoate (3-endo,8-syn)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane 8-Azoniabicyclo[3.2.1]octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-,(3-endo,8-syn)- Apo-Ipravent BDBM50355610 CHEMBL1615433 Ipratropium bromide monohydrate MRF-0000591 Rhinotrop SPBio_002609 3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-methyl-8-(propan-2-yl)-8-azoniabicyclo[3.2.1]octane AB01274716_02 Atronase Bitrop Disne-Asmol Ipvent NC00569 NCGC00163226-01 Rinoberen X8M Aerodose Atrovent Hfa CHEBI:91495 Ipatropium Bromide LS-187321 Prestwick1_000575 SCHEMBL14311544 [(1R,5S)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate (8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate Apovent BDBM50378083 CTK5B1121 Ipravent N-Isopropylatropine Rhinovent STL483422 AC1L1GMB Atrovent (TN) BRD-A05352148-004-02-0 GTPL325 Kendral-Ipratropium NCGC00018212-04 NSC_3746 Rinovagos [(1R,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate (+-)-Ipratropine 60205-81-4 Aerovent Atrovent Nasal CHEMBL1237108 MCULE-9149653773 [ Show all ]
Inchi Key	OEXHQOGQTVQTAT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H30NO3/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15/h4-8,14,16-19,22H,9-13H2,1-3H3/q+1
PubChem CID	3746
ChEMBL	N/A
IUPHAR	325
BindingDB	50355610, 50378083, 82372
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.21 nM	PMID2250662	BindingDB

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