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GPCR

NameProstaglandin E2 receptor EP1 subtype
SpeciesHomo sapiens (Human)
GenePTGER1
SynonymPGE receptor EP1 subtype
EP1 receptor
prostaglandin E receptor 1 (subtype EP1), 42kDa
Prostanoid EP1 receptor
EP1 prostanoid receptor
[ Show all ]
DiseaseUnspecified
Thrombosis
Pollakiuria
Pain
Length402
Amino acid sequenceMSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
UniProtP34995
Protein Data BankN/A
GPCR-HGmod modelP34995
3D structure modelThis predicted structure model is from GPCR-EXP P34995.
BioLiPN/A
Therapeutic Target DatabaseT15497
ChEMBLCHEMBL1811
IUPHAR340
DrugBankBE0000064

Ligand

NameCHEMBL388655
Molecular formulaC25H20ClFO3
IUPAC name3-[2-[2-[(4-chloro-2-fluorophenyl)methoxy]phenyl]cyclopenten-1-yl]benzoic acid
Molecular weight422.88
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP6.0
SynonymsSCHEMBL5620109
Inchi KeyBHDXKCMVCKNNED-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H20ClFO3/c26-19-12-11-18(23(27)14-19)15-30-24-10-2-1-7-22(24)21-9-4-8-20(21)16-5-3-6-17(13-16)25(28)29/h1-3,5-7,10-14H,4,8-9,15H2,(H,28,29)
PubChem CID10216528
ChEMBLCHEMBL388655
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5050.12 nMPMID17084082ChEMBL

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