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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Sphingosine 1-phosphate receptor 2
Species	Homo sapiens (Human)
Gene	S1PR2
Synonym	Endothelial differentiation G-protein coupled receptor 5 Sphingosine 1-phosphate receptor Edg-5 S1P2 receptor S1P2 S1P receptor Edg-5 S1P receptor 2 edg5 endothelial differentiation G protein-coupled receptor 5 GPCR18 Gpcr13 G protein-coupled receptor 13 [ Show all ]
Disease	Hypertension
Length	353
Amino acid sequence	MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
UniProt	O95136
Protein Data Bank	N/A
GPCR-HGmod model	O95136
3D structure model	This predicted structure model is from GPCR-EXP O95136.
BioLiP	N/A
Therapeutic Target Database	T47888
ChEMBL	CHEMBL2955
IUPHAR	276
DrugBank	N/A

Ligand

Name	SR-01000759095-1
Molecular formula	C25H25N3O3
IUPAC name	5-benzyl-3-[2-(1-benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]imidazolidine-2,4-dione
Molecular weight	415.493
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.7
Synonyms	MolPort-004-175-783 5-benzyl-3-[2-(1-benzyl-2,5-dimethyl-pyrrol-3-yl)-2-keto-ethyl]hydantoin BDBM41705 1009250-20-7 cid_16315617 5-benzyl-3-[2-(1-benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]imidazolidine-2,4-dione 3-[2-[2,5-dimethyl-1-(phenylmethyl)-3-pyrrolyl]-2-oxoethyl]-5-(phenylmethyl)imidazolidine-2,4-dione MCULE-9355022570 5-benzyl-3-[2-(1-benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxoethyl]imidazolidine-2,4-dione AKOS000929077 Z15789088 CHEMBL1474928 3-[2-[2,5-dimethyl-1-(phenylmethyl)pyrrol-3-yl]-2-oxidanylidene-ethyl]-5-(phenylmethyl)imidazolidine-2,4-dione [ Show all ]
Inchi Key	BHCZNTCIKKBOAN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H25N3O3/c1-17-13-21(18(2)27(17)15-20-11-7-4-8-12-20)23(29)16-28-24(30)22(26-25(28)31)14-19-9-5-3-6-10-19/h3-13,22H,14-16H2,1-2H3,(H,26,31)
PubChem CID	16315617
ChEMBL	CHEMBL1474928
IUPHAR	N/A
BindingDB	41705
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<30000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL
EC50	<44000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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