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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H3 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh3
Synonym	GPCR97 H3 receptor H3R HH3R
Disease	N/A for non-human GPCRs
Length	445
Amino acid sequence	MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
UniProt	Q9QYN8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4124
IUPHAR	264
DrugBank	N/A

Ligand

Name	CHEMBL112504
Molecular formula	C10H10N4O2S
IUPAC name	2-[2-(1H-imidazol-5-yl)ethylsulfanyl]-5-nitropyridine
Molecular weight	250.276
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	1.7
Synonyms	2-{2-[1H-Imidazol-4-yl]ethylthio}-5-nitropyridine SCHEMBL7853275 BGSRSMTXDSZDMZ-UHFFFAOYSA-N 152030-16-5 L011451 UCL-1199 2-[2-(1H-Imidazol-4-yl)-ethylsulfanyl]-5-nitro-pyridine Pyridine, 2-[[2-(1H-imidazol-5-yl)ethyl]thio]-5-nitro- BDBM50033042 [ Show all ]
Inchi Key	BGSRSMTXDSZDMZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H10N4O2S/c15-14(16)9-1-2-10(12-6-9)17-4-3-8-5-11-7-13-8/h1-2,5-7H,3-4H2,(H,11,13)
PubChem CID	10220586
ChEMBL	CHEMBL112504
IUPHAR	N/A
BindingDB	50033042
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4.8 nM	PMID7650687, PMID8809168	BindingDB,ChEMBL

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