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GPCR

Name	Alpha-2C adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2c
Synonym	alpha2C-adrenoceptor alpha2-C4 Alpha-2CAR alpha-2C adrenoreceptor Alpha-2C adrenoceptor alpha-2C adrenergic receptor alpha-2 adrenergic receptor subtype C4 adrenergic receptor Adrenergic alpha2C- receptor class I ADRA2RL2 ADRA2L2 Adra-2c [ Show all ]
Disease	N/A for non-human GPCRs
Length	458
Amino acid sequence	MASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWGPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRGPAGPDGASPTTENGLGKAAGENGHCAPPRTEVEPDESSAAERRRRRGALRRGGRRREGAEGDTGSADGPGPGLAAEQGARTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P22086
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL314
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	sulpiride
Molecular formula	C15H23N3O4S
IUPAC name	N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular weight	341.426
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	0.6
Synonyms	GTPL5501 5-22-08-00105 (Beilstein Handbook Reference) HMS3372O01 AKOS004912732 Isnamide Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (S)- Levopraid BPBio1_000463 LP01050 Calmoflorine Miradol CHEMBL26 N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Desmenat Dresent (+/-)-Sulpiride Enimon Omiryl Prestwick_431 Restful SPBio_002132 Sulperide Sulpiride, British Pharmacopoeia (BP) Reference Standard Sulpitil Tox21_501050 NCGC00015966-06 NCGC00261735-01 EU-0101050 15676-16-1 HMS2095K13 AB0105833 HMS3712K13 AN-1019 KBio1_000278 Benzamide,5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Levosulpiride [INN] BRD-A55272860-001-04-7 Magnetic resonance imaging sulpiride CCRIS 4248 MLS000069434 CTK8F2082 N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide Dobren (+)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide DSSTox_RID_80050 (plusmn)-sulpiride Ozoderpin Pyrikappl S0501 SR-01000075402-2 Sulpirida [INN-Spanish] SULPIRIDE,(+) Sulpyrid Zemorcon NCGC00024852-02 Norestran (RS)-(A+/-)-Sulpiride Fidelan 5-(Aminosulfonyl)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-2-methoxy- benzamide HMS3266P12 AC1L1K62 I06-0054 BDBM11638 L-Sulpiride Biomol-NT_000162 Lisopiride BSPBio_000211 Meresa CHEBI:32168 N-(((S)-1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Dogmatyl (TN) (+/-)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide Eglonyl o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl- Prestwick2_000056 R.D. 1403 Sernevin Stamonevrol Sulpiride 1.0 mg/ml in Methanol Sulpiridum Synedil NCGC00015966-04 NCGC00024852-05 Equilid 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl)pyrrolidine Guastil HMS3393A08 Alimoral J10067 Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Levosulpirida BPBio1_001255 LS-20058 CAS-15676-16-1 Mirbanil Coolspan N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoyl-benzamide DivK1c_000278 ( inverted question mark)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide DSSTox_CID_22574 (.+/-.)-Sulpiride Omperan Psicocen RV-12309 Splotin Sulpirid Sulpiride, European Pharmacopoeia (EP) Reference Standard Sulpor Valirem NCGC00015966-07 Neogama Eusulpid 5-(Aminosufonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide HMS2231K07 Abilit HMS500N20 BCP04500 KS-00000YBQ BGRJTUBHPOOWDU-UHFFFAOYSA-N Levosulpiridum BRD-A55272860-001-08-8 Mariastel CCRIS-4248 MLS001306443 D01226 Dogmatil (+-)-sulpiride DTXSID1042574 (RS)-(+/-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Normum Prestwick0_000056 Pyrkappl s4655 SR-01000075402-3 SULPIRIDE,(-) Suprium N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide NCGC00024852-03 (y)-Sulpiride FT-0652244 5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-benzamide HMS3371P16 Aiglonyl IDI1_000278 Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy- L000579 BPBio1_000233 Lopac0_001050 C15H23N3O4S MFCD00055061 N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide DB00391 Dolmatil (+/-)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide EINECS 239-753-7 o-ANISAMIDE, N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-SULFAMOYL-, (S)-(-)- Prestwick3_000056 RD 1403 SMR000038923 STK368596 Sulpiride [USAN:INN:BAN:JAN] Sulpiridum [INN-Latin] Tox21_302205 NCGC00015966-05 NCGC00255813-01 EU-0001755 HMS1568K13 676S161 HMS3651G12 AN-1017 KB-295026 Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoyl-, S-(-)- Levosulpirida [INN-Spanish] BRD-A55272860-001-03-9 LS-20059 CCG-205127 Misulvan CS-4534 N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide dl-sulpiride ( inverted question mark)-Sulpiride DSSTox_GSID_42574 (?)-Sulpiride Oprea1_602476 PubChem17241 S 8010 SR-01000075402 Sulpirida Sulpiride, SLP Sulpride Z84655412 NCGC00015966-08 NINDS_000278 (RS)-(+/-)-sulpiride Fardalan 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide HMS3263A22 AC-12181 HY-B1019 BCP13871 Kylistro Biomol-NT_000037 Levosulpiridum [INN-Latin] BRN 0494008 MCULE-7506797476 Championyl MolPort-002-070-475 Darleton Dogmatyl (+/-)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Eglonil Nufarol Prestwick1_000056 R. D. 1403 SCHEMBL8421 SR-01000075402-6 Sulpiride (JP17/USAN/INN) Sulpiride-R Sursumid NCGC00015966-03 NCGC00024852-04 [ Show all ]
Inchi Key	BGRJTUBHPOOWDU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
PubChem CID	5355
ChEMBL	CHEMBL26
IUPHAR	5501
BindingDB	11638
DrugBank	DB00391
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	682.0 nM	PMID2885406	BindingDB
Ki	4300.0 nM	PMID2138666	BindingDB
Ki	6118.0 nM	PMID2885406	BindingDB
Ki	7880.0 nM	PMID2869639	BindingDB

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