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GPCR

NameHistamine H2 receptor
SpeciesMus musculus (Mouse)
GeneHrh2
SynonymGastric receptor I
H2 receptor
H2R
HH2R
DiseaseN/A for non-human GPCRs
Length397
Amino acid sequenceMEPNGTVHSCCLDSIALKVTISVVLTTLIFITVAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQLSFKWSFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDDAVNEVVEGIVLWLGYANSALNPILYATLNRDFRMAYQQLFHCKLASHNSHKTSLRLNNSLLSRSQSREGRWQEEKPLKLQVWSGTELTHPQGSPVRTRLSHSSCLLSLSLLSFIWKLGTWIHHRRPFQPSLHISA
UniProtP97292
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2245
IUPHARN/A
DrugBankN/A

Ligand

Namehistamine
Molecular formulaC5H9N3
IUPAC name2-(1H-imidazol-5-yl)ethanamine
Molecular weight111.148
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP-0.7
SynonymsHistamium
Spectrum_000845
IDI1_000308
WLN: T5M CNJ D2Z
KB-220202
[ Show all ]
Inchi KeyNTYJJOPFIAHURM-UHFFFAOYSA-N
Inchi IDInChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
PubChem CID774
ChEMBLCHEMBL90
IUPHAR1204, 1247
BindingDB7966, 50121205
DrugBankDB05381

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Relative potency1.0 -PMID2959777ChEMBL

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