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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	G-protein coupled receptor homolog US28
Species	Human cytomegalovirus (strain AD169) (HHV-5)
Gene	US28
Synonym	HHRF3
Disease	N/A for non-human GPCRs
Length	354
Amino acid sequence	MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
UniProt	P69332
Protein Data Bank	4xt1
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4xt1.
BioLiP	BL0309402,BL0309403
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4259
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL198614
Molecular formula	C27H29Cl2NO
IUPAC name	4-(4-chlorophenyl)-1-[4-(4-chlorophenyl)-4-phenylbutyl]piperidin-4-ol
Molecular weight	454.435
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	6.8
Synonyms	4-(4-Chloro-phenyl)-1-[4-(4-chloro-phenyl)-4-phenyl-butyl]-piperidin-4-ol BDBM50027199
Inchi Key	NSPOZVUXYQBLBO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H29Cl2NO/c28-24-12-8-22(9-13-24)26(21-5-2-1-3-6-21)7-4-18-30-19-16-27(31,17-20-30)23-10-14-25(29)15-11-23/h1-3,5-6,8-15,26,31H,4,7,16-20H2
PubChem CID	11525302
ChEMBL	CHEMBL198614
IUPHAR	N/A
BindingDB	50027199
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	17000.0 nM	PMID16190772	BindingDB,ChEMBL

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