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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Rattus norvegicus (Rat)
Gene	Chrm2
Synonym	cholinergic receptor cholinergic receptor, muscarinic 2 AChR M2 Chrm-2 M2 muscarinic acetylcholine receptor M2 receptor cholinergic receptor, muscarinic 2, cardiac [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P10980
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL309
IUPHAR	14
DrugBank	N/A

Ligand

Name	tropicamide
Molecular formula	C17H20N2O2
IUPAC name	N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide
Molecular weight	284.359
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	1.5
Synonyms	T 9778 Lopac0_001223 BDBM82371 Tropicamida MLS002154240 Bournonville Brand of Tropicamide Tropicamide for peak identification, European Pharmacopoeia (EP) Reference Standard N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide CAS-1508-75-4 Tropicamide Rivex Brand n-ethyl-n-(g-picolyl)tropamide component of Paremyd Tropicamide, United States Pharmacopeia (USP) Reference Standard NCGC00016065-09 DivK1c_000448 NINDS_000448 Prestwick2_000228 EU-0101223 Ocusoft Brand of Tropicamide SAM002564235 HMS2235J15 SPECTRUM1500599 HY-B0321 AB00052120_12 SR-01000075351-3 KBio2_003632 Akorn Brand of Tropicamide AM84467 Tox21_110297_1 MCULE-4102613027 Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-, (+-)- Tropicamide (JP15/USP/INN) Mydriacyl BRD-A79672927-001-10-8 Tropicamide Monohydrochloride, (R)-Isomer N-ethyl-3-hydroxy-2-phenyl-N-(4-pyridylmethyl)propanamide Chauvin Brand of Tropicamide Tropicamide, (+-)-Isomer NCGC00016065-04 CTK4C6796 Tropikamid NCGC00024866-03 Paremyd DSSTox_RID_80757 NSC757372 Q-201902 HMS1568N17 SMP1_000304 HMS3267A13 508T754 Spectrum4_000377 I06-0811 AC-816 ST51015162 KBioGR_000873 KS-5174 BBL028074 Tropicacyl Minims tropicamide BGDKAVGWHJFAGW-UHFFFAOYSA-N Tropicamide Chauvin Brand Mydriaticum BSPBio_002289 Tropicamide Ocumed Brand N-Ethyl-N-(4-pyridylmethyl)tropamid CHEMBL1200604 Tropicamide, European Pharmacopoeia (EP) Reference Standard NCGC00016065-07 NCGC00024866-06 Prestwick0_000228 EINECS 216-140-2 Ocu-Tropic RP29909 HMS2092A18 SPBio_002196 HMS3712N17 AB00052120-10 SR-01000075351 KBio1_000448 ACN-036667 Stulln Brand 2 of Tropicamide TL8001101 LP01223 Benzeneacetamide, N-ethyl-.alpha.-(hydroxymethyl)-N-(4-pyridinylmethyl)- Tropicamida [INN-Spanish] MolPort-000-159-321 BPBio1_000303 Tropicamide Minims N-Ethyl-2-phenyl-N-4-[-pyridyl-methyl]hydracrylamide CAS_1508-75-4 Tropicamide [USAN:INN:BANJAN] NC00589 CPD000058523 Tropicamidum NCGC00016065-11 DSSTox_CID_25220 Novartis Brand of Tropicamide Prestwick3_000228 FT-0657590 OcuTropic SBI-0051190.P003 HMS3259M18 1508-75-4 Spectrum2_000936 Hydracrylamide, N-ethyl-2-phenyl-N-(4-pyridylmethyl)- AB0011259 SR-01000075351-5 KBio2_006200 AKOS005664076 AN-15530 Tox21_501223 Medical Ophthalmics Brand of Tropicamide Benzeneacetamide,N-ethyl-a-(hydroxymethyl)-N-(4-pyridinylmethyl)- Tropicamide (JP17/USP/INN) Mydriacyl (TN) BRN 0285563 Tropicamide Monohydrochloride, (S)-Isomer N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide CHEBI:9757 Tropicamide, (R)-Isomer NCGC00016065-05 D00397 Tropimil NCGC00024866-04 Pharmafair Brand of Tropicamide DTXSID8045220 NSC_5593 Rivex Brand of Tropicamide HMS1921I09 SMR000058523 HMS3373B07 Spectrum5_001585 IDI1_000448 AC1L1KOZ STK934612 KBioSS_001064 SW196691-3 L001262 BCP13504 Tropicamid MLS001306442 Bistropamide Tropicamide Faure Mydrum Cahill May Roberts Brand of Tropicamide Tropicamide Pharmafair Brand N-Ethyl-N-(4-pyridylmethyl)tropamide Colircusi Tropicamida Tropicamide, solid NCGC00016065-08 DB00809 NCGC00261908-01 Prestwick1_000228 Epitromina Ocumed Brand of Tropicamide s1913 HMS2095N17 (+-)-N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide Spectro-Cyl HMS501G10 AB00052120_11 SR-01000075351-1 KBio2_001064 AK164485 Tox21_110297 LS-28545 Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)- Mydral BRD-A79672927-001-05-8 Tropicamide Monofree N-Ethyl-3-hydroxy-2-phenyl-N-(4-pyridinylmethyl)propanamide # CCG-40076 Tropicamide [USAN:USP:INN:BAN:JAN] NCGC00016065-03 CS-2362 Tropicamidum [INN-Latin] NCGC00024866-02 Opticyl DSSTox_GSID_45220 NSC-757372 Prestwick_487 GTPL7319 SCHEMBL23975 HMS3263F08 5-22-09-00359 (Beilstein Handbook Reference) Spectrum3_000655 I-Picamide AB2000370 SR-01000075351-7 KBio3_001509 Alcon Brand of Tropicamide API0004531 Triaminic DM MFCD00058580 BG0349 Tropicamide Alcon Brand Mydriafair BSPBio_000275 Tropicamide Novartis Brand N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide Tropicamide, (S)-Isomer NCGC00016065-06 D09PNY Visumidriatic NCGC00024866-05 Pharmakon1600-01500599 EBD22886 Ocu Tropic Ro 1-7683 HMS2089M05 SPBio_000872 HMS3651K04 AB00052120 Spectrum_000584 K-4793 AC1Q5IFA Stulln Brand 1 of Tropicamide KS-00000H8Q [ Show all ]
Inchi Key	BGDKAVGWHJFAGW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
PubChem CID	5593
ChEMBL	CHEMBL1200604
IUPHAR	N/A
BindingDB	82371
DrugBank	DB00809
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	50.12 nM	PMID2250662	BindingDB

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