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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Rattus norvegicus (Rat)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P08482
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL276
IUPHAR	13
DrugBank	N/A

Ligand

Name	Amperozide
Molecular formula	C23H29F2N3O
IUPAC name	4-[4,4-bis(4-fluorophenyl)butyl]-N-ethylpiperazine-1-carboxamide
Molecular weight	401.502
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.1
Synonyms	Amperozide [INN:BAN] CHEBI:92913 FG-5606 NCGC00015081-03 75558-90-6 API0008640 D0V4JO Lopac-A-6976 PDSP2_000730 1-Piperazinecarboxamide, 4-(4,4-bis(p-fluorophenyl)butyl)-N-ethyl- AKOS030548015 C23H29F2N3O DTXSID6048416 NCGC00015081-01 ZINC4214849 Amperozidum Hogpax vet. NCGC00162051-01 AC1L2JOA BDBM50311786 Lopac0_000040 SCHEMBL340961 4-(4,4-Bis(4-fluorphenyl)butyl)-N-ethyl-1-piperazinecarboxamid Amperozida Amperozide [BAN:INN] CCG-204136 FG 5606 NCGC00015081-02 75529-73-6 (hydrochloride) Amperozidum [INN-Latin] CHEMBL1079935 L000997 PDSP1_000742 0M2W3TAG39 AC1Q4NM7 Amperozida [INN-Spanish] BRD-K52397688-001-01-9 DB08927 LS-177195 UNII-0M2W3TAG39 4-(4,4-Bis(p-fluorophenyl)butyl)-N-ethyl-1-piperazinecarboxamide [ Show all ]
Inchi Key	NNAIYOXJNVGUOM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H29F2N3O/c1-2-26-23(29)28-16-14-27(15-17-28)13-3-4-22(18-5-9-20(24)10-6-18)19-7-11-21(25)12-8-19/h5-12,22H,2-4,13-17H2,1H3,(H,26,29)
PubChem CID	73333
ChEMBL	CHEMBL1079935
IUPHAR	N/A
BindingDB	50311786
DrugBank	DB08927
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	17782.8 nM	PubChem BioAssay data set	ChEMBL

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