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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H2 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH2
Synonym	Gastric receptor I H2R HH2R
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProt	P47747
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2882
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL61675
Molecular formula	C21H25FN6
IUPAC name	1-[3-(3-fluorophenyl)-3-pyridin-2-ylpropyl]-2-[3-(1H-imidazol-5-yl)propyl]guanidine
Molecular weight	380.471
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	2.4
Synonyms	SCHEMBL7290048 1-[3-(3-Fluorophenyl)-3-(2-pyridyl)propyl]-3-[3-(1H-imidazol-4-yl)propyl]guanidine BDBM50406068
Inchi Key	BFIAWQUMMUHFNN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H25FN6/c22-17-6-3-5-16(13-17)19(20-8-1-2-10-25-20)9-12-27-21(23)26-11-4-7-18-14-24-15-28-18/h1-3,5-6,8,10,13-15,19H,4,7,9,11-12H2,(H,24,28)(H3,23,26,27)
PubChem CID	14660357
ChEMBL	CHEMBL61675
IUPHAR	N/A
BindingDB	50406068
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Intrinsic activity	0.5 -	PMID2569042	ChEMBL
Intrinsic activity	1.0 -	PMID2569042	ChEMBL
pD2	7.79 -	PMID2569042	ChEMBL
pD2	7.88 -	PMID2569042	ChEMBL
Relative potency	75.9 -	PMID2569042	ChEMBL

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