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GLASS

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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Homo sapiens (Human)
Gene	CHRM1
Synonym	cholinergic receptor cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS Chrm-1 M1 receptor M1R M1 muscarinic acetylcholine receptor [ Show all ]
Disease	Functional bowel syndrome; Irritable bowel syndrome Glaucoma Peptic ulcer Parkinsonism; Extrapyramidal disorders secondary to neuroleptic drug therapy Visceral spasms Parkinson's disease; Dystonia Parkinson's disease Neurological disease Neuropathic pain Overactive bladder disorder Excessive sweating; Stomach ulcer Cognitive disorders Chronic obstructive pulmonary disease Schizophrenia Schizophrenia; Dementia Schizophrenia; Schizoaffective disorders Unspecified Urinary incontinence Anesthesia Alzheimer disease Abdominal stomach pain; Irritable bowel syndrome [ Show all ]
Length	460
Amino acid sequence	MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P11229
Protein Data Bank	5cxv
GPCR-HGmod model	P11229
3D structure model	This structure is from PDB ID 5cxv.
BioLiP	BL0339262, BL0339261, BL0339263
Therapeutic Target Database	T28893
ChEMBL	CHEMBL216
IUPHAR	13
DrugBank	BE0000092

Ligand

Name	suloctidil
Molecular formula	C20H35NOS
IUPAC name	(1S,2R)-2-(octylamino)-1-(4-propan-2-ylsulfanylphenyl)propan-1-ol
Molecular weight	337.566
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	5.8
Synonyms	CS-4883 MLS001148124 SCHEMBL13613541 UNII-XV1N1XY17K component BFCDFTHTSVTWOG-YLJYHZDGSA-N (alphaS)-alpha-[(R)-1-(Octylamino)ethyl]-4-[(1-methylethyl)thio]benzenemethanol BRD-K42635745-001-02-4 HMS2096E04 NCGC00022213-03 SR-01000000281-3 (1S,2R)-1-(4-(isopropylthio)phenyl)-2-(octylamino)propan-1-ol AB00383060 CCG-220421 CHEMBL588119 HY-B1237 REGID_for_CID_657255 Suloctidil (USAN/INN) (1S,2R)-2-(octylamino)-1-(4-propan-2-ylsulfanylphenyl)propan-1-ol BDBM67714 D05967 MLS002222281 SMR000058933 ZINC2561289 (R,S)-4-((1-Methylethyl)thio)-alpha-(1-(octylamino)ethyl)benzenemethanol BRD-K42635745-001-22-2 CHEBI:92751 HMS2230I12 Opera_ID_1631 ST51015124 (1S,2R)-1-[4-(isopropylthio)phenyl]-2-(octylamino)propan-1-ol AC1LCW9C cid_657255 MLS000028666 SBB058183 Suloctidil, analytical standard, for drug analysis (1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol BPBio1_000444 GNF-Pf-1859 MLS002695978 SR-01000000281 54767-75-8 BSPBio_000402 HMS3713E04 Prestwick3_000421 (1S,2R)-1-[4-(methylethylthio)phenyl]-2-(octylamino)propan-1-ol AKOS024374991 [ Show all ]
Inchi Key	BFCDFTHTSVTWOG-YLJYHZDGSA-N
Inchi ID	InChI=1S/C20H35NOS/c1-5-6-7-8-9-10-15-21-17(4)20(22)18-11-13-19(14-12-18)23-16(2)3/h11-14,16-17,20-22H,5-10,15H2,1-4H3/t17-,20-/m1/s1
PubChem CID	657255
ChEMBL	CHEMBL588119
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4505.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	1085.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL

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