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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M3
Species	Mus musculus (Mouse)
Gene	Chrm3
Synonym	cholinergic receptor, muscarinic 3 cholinergic receptor, muscarinic 3, cardiac Chrm-3 cholinergic receptor M3 receptor M3R Mm3 mAChR HM4 [ Show all ]
Disease	N/A for non-human GPCRs
Length	589
Amino acid sequence	MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVSQLDSYNISQTSGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGTKRSSRRKYGGCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPDKDLGTMDVERNAHKLQAQKSMDDRDNCQKDFSKLPIQLESAVDTAKTSDTNSSVDKTTAALPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
UniProt	Q9ERZ3
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	158930-48-4
Molecular formula	C7H12N2O2
IUPAC name	methyl 6-amino-2,3,4,5-tetrahydropyridine-3-carboxylate
Molecular weight	156.185
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	-1.0
Synonyms	L008011 AKOS027399303 CHEMBL553602 3-pyridinecarboxylic acid,6-amino-2,3,4,5-tetrahydro-,methyl ester Methyl 6-amino-2,3,4,5-tetrahydropyridine-3-carboxylate 6-Amino-2,3,4,5-tetrahydro-3-pyridinecarboxylic acid methyl ester BDBM50039848 158832-45-2 KB-184721 3-Pyridinecarboxylicacid,6-amino-2,3,4,5-tetrahydro-,methylester(9CI) SCHEMBL8309304 6-Amino-2,3,4,5-tetrahydro-pyridine-3-carboxylic acid methyl ester; hydrochloride CHEMBL1194965 [ Show all ]
Inchi Key	NDYOGNUJWRYXIH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C7H12N2O2/c1-11-7(10)5-2-3-6(8)9-4-5/h5H,2-4H2,1H3,(H2,8,9)
PubChem CID	10012139
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50039848
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	14000.0 nM	PMID9111297	BindingDB

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