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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL597222
Molecular formulaC17H14Cl2N2O3
IUPAC name5-[[4-(2,4-dichlorophenoxy)phenyl]methyl]-1-methylimidazolidine-2,4-dione
Molecular weight365.21
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.9
SynonymsN/A
Inchi KeyADEZZPOFGABOAN-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H14Cl2N2O3/c1-21-14(16(22)20-17(21)23)8-10-2-5-12(6-3-10)24-15-7-4-11(18)9-13(15)19/h2-7,9,14H,8H2,1H3,(H,20,22,23)
PubChem CID46231389
ChEMBLCHEMBL597222
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity2.0 %PMID20064714ChEMBL

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