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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	CHEMBL1734241
Molecular formula	C18H19F3N4O4S2
IUPAC name	2-[[2-[4-[2-(trifluoromethyl)phenyl]sulfonylpiperazin-1-yl]acetyl]amino]thiophene-3-carboxamide
Molecular weight	476.489
Hydrogen bond acceptor	10
Hydrogen bond donor	2
XlogP	2.1
Synonyms	HMS3053F09 870698-01-4 MolPort-005-325-151 Z31017859 2-(2-(4-(2-(trifluoromethyl)phenylsulfonyl)piperazin-1-yl)acetamido)thiophene-3-carboxamide MCULE-7093763854 AKOS034150207 NCGC00241095-01 ZINC35963748 2-(2-{4-[2-(trifluoromethyl)benzenesulfonyl]piperazin-1-yl}acetamido)thiophene-3-carboxamide MLS002166283 BDBM50342351 SMR001248633 [ Show all ]
Inchi Key	AAAZRMGPBSWFDK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H19F3N4O4S2/c19-18(20,21)13-3-1-2-4-14(13)31(28,29)25-8-6-24(7-9-25)11-15(26)23-17-12(16(22)27)5-10-30-17/h1-5,10H,6-9,11H2,(H2,22,27)(H,23,26)
PubChem CID	16231644
ChEMBL	CHEMBL1734241
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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