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GLASS

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GPCR

Name	Prostaglandin E2 receptor EP1 subtype
Species	Homo sapiens (Human)
Gene	PTGER1
Synonym	PGE receptor EP1 subtype EP1 receptor prostaglandin E receptor 1 (subtype EP1), 42kDa Prostanoid EP1 receptor EP1 prostanoid receptor PGE2 receptor EP1 subtype [ Show all ]
Disease	Unspecified Thrombosis Pollakiuria Pain
Length	402
Amino acid sequence	MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
UniProt	P34995
Protein Data Bank	N/A
GPCR-HGmod model	P34995
3D structure model	This predicted structure model is from GPCR-EXP P34995.
BioLiP	N/A
Therapeutic Target Database	T15497
ChEMBL	CHEMBL1811
IUPHAR	340
DrugBank	BE0000064

Ligand

Name	CHEMBL403459
Molecular formula	C20H18ClNO3
IUPAC name	1-[(5-chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrrole-3-carboxylic acid
Molecular weight	355.818
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.3
Synonyms	SCHEMBL5469113 BDBM50423568
Inchi Key	BEPSWSOFMIKFDW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H18ClNO3/c1-14-9-17(20(23)24)12-22(14)11-16-10-18(21)7-8-19(16)25-13-15-5-3-2-4-6-15/h2-10,12H,11,13H2,1H3,(H,23,24)
PubChem CID	44455299
ChEMBL	CHEMBL403459
IUPHAR	N/A
BindingDB	50423568
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	158.0 nM	PMID18262416	BindingDB
IC50	158.49 nM	PMID18262416	ChEMBL

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