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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Follicle-stimulating hormone receptor
Species	Homo sapiens (Human)
Gene	FSHR
Synonym	Follitropin receptor FSH receptor FSH-R LGR1
Disease	Female infertility African trypanosomiasis Contraception Ovarian cancer
Length	695
Amino acid sequence	MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN
UniProt	P23945
Protein Data Bank	4mqw
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4mqw.
BioLiP	BL0274372
Therapeutic Target Database	T68334
ChEMBL	CHEMBL2024
IUPHAR	N/A
DrugBank	BE0000387

Ligand

Name	CHEMBL192868
Molecular formula	C34H34N2O3
IUPAC name	N-(1-acetyl-8-methoxy-2,2,4-trimethyl-4-phenyl-3H-quinolin-6-yl)-4-phenylbenzamide
Molecular weight	518.657
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	6.7
Synonyms	BDBM50410308 MZFKNJKCVTUDFM-UHFFFAOYSA-N 1-Acetyl-6-(4-phenylbenzoyl)amino-8-methoxy-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline SCHEMBL1323159
Inchi Key	MZFKNJKCVTUDFM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C34H34N2O3/c1-23(37)36-31-29(34(4,22-33(36,2)3)27-14-10-7-11-15-27)20-28(21-30(31)39-5)35-32(38)26-18-16-25(17-19-26)24-12-8-6-9-13-24/h6-21H,22H2,1-5H3,(H,35,38)
PubChem CID	11203161
ChEMBL	CHEMBL192868
IUPHAR	N/A
BindingDB	50410308
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	30.0 nM	PMID15771412	BindingDB,ChEMBL

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