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GPCR

NameNeuropeptide Y receptor type 5
SpeciesRattus norvegicus (Rat)
GeneNpy5r
Synonymfood intake receptor
neuropeptide Y receptor type 5
NPY-Y5 receptor
NPY5-R
NPYY5-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length445
Amino acid sequenceMEFKLEEHFNKTFVTENNTAAARNAAFPAWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLQPSKKSRNQAKTPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQGKHLAVPENPASVRSQLSPSSKVIPGVPICFEVKPEESSDAHEMRVKRSITRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
UniProtQ63634
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2548
IUPHAR308
DrugBankN/A

Ligand

NameCHEMBL193770
Molecular formulaC23H25N3O5
IUPAC namemethyl 2-[[2-[4-(2-oxo-4H-3,1-benzoxazin-1-yl)piperidin-1-yl]acetyl]amino]benzoate
Molecular weight423.469
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP3.2
SynonymsSCHEMBL3383536
2-{2-[4-(2-Oxo-4H-benzo[d][1,3]oxazin-1-yl)-piperidin-1-yl]-acetylamino}-benzoic acid methyl ester
BDBM50163537
Inchi KeyMVDVEGBLJYBZDI-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H25N3O5/c1-30-22(28)18-7-3-4-8-19(18)24-21(27)14-25-12-10-17(11-13-25)26-20-9-5-2-6-16(20)15-31-23(26)29/h2-9,17H,10-15H2,1H3,(H,24,27)
PubChem CID10025311
ChEMBLCHEMBL193770
IUPHARN/A
BindingDB50163537
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<1000.0 nMPMID15771450BindingDB,ChEMBL

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