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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Sphingosine 1-phosphate receptor 2
Species	Homo sapiens (Human)
Gene	S1PR2
Synonym	Endothelial differentiation G-protein coupled receptor 5 Sphingosine 1-phosphate receptor Edg-5 S1P2 receptor S1P2 S1P receptor Edg-5 S1P receptor 2 edg5 endothelial differentiation G protein-coupled receptor 5 GPCR18 Gpcr13 G protein-coupled receptor 13 [ Show all ]
Disease	Hypertension
Length	353
Amino acid sequence	MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
UniProt	O95136
Protein Data Bank	N/A
GPCR-HGmod model	O95136
3D structure model	This predicted structure model is from GPCR-EXP O95136.
BioLiP	N/A
Therapeutic Target Database	T47888
ChEMBL	CHEMBL2955
IUPHAR	276
DrugBank	N/A

Ligand

Name	CHEMBL324358
Molecular formula	C15H33N2O5P
IUPAC name	[(2S)-2-amino-3-(dodecylamino)-3-oxopropyl] dihydrogen phosphate
Molecular weight	352.412
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	0.2
Synonyms	CHEMBL1183918 Phosphoric acid mono-((S)-2-amino-2-dodecylcarbamoyl-ethyl) ester; TFA BDBM50133427 N-Dodecyl-O-phosphono-L-serinamide
Inchi Key	BDKXPSCUPFJXEP-AWEZNQCLSA-N
Inchi ID	InChI=1S/C15H33N2O5P/c1-2-3-4-5-6-7-8-9-10-11-12-17-15(18)14(16)13-22-23(19,20)21/h14H,2-13,16H2,1H3,(H,17,18)(H2,19,20,21)/t14-/m0/s1
PubChem CID	44342221
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50133427
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	973.2 nM	PMID14505636	BindingDB

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