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Name | Adenosine receptor A2b |
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Species | Homo sapiens (Human) |
Gene | ADORA2B |
Synonym | adenosine receptor A2b A2BR A2B receptor A2b |
Disease | Paroxysmal supraventricular tachycardia Non-insulin dependent diabetes Hypertension Herpes simplex virus infection Apnea [ Show all ] |
Length | 332 |
Amino acid sequence | MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL |
UniProt | P29275 |
Protein Data Bank | N/A |
GPCR-HGmod model | P29275 |
3D structure model | This predicted structure model is from GPCR-EXP P29275. |
BioLiP | N/A |
Therapeutic Target Database | T86679 |
ChEMBL | CHEMBL255 |
IUPHAR | 20 |
DrugBank | BE0000241 |
Name | 1,3-Dipropylxanthine |
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Molecular formula | C11H16N4O2 |
IUPAC name | 1,3-dipropyl-7H-purine-2,6-dione |
Molecular weight | 236.275 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 1.9 |
Synonyms | 1,3-Dipropyl-3,7-dihydro-purine-2,6-dione BDBM50227331 D0R3DN NSC_169317 UNII-Z02T66W92D [ Show all ] |
Inchi Key | MJVIGUCNSRXAFO-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C11H16N4O2/c1-3-5-14-9-8(12-7-13-9)10(16)15(6-4-2)11(14)17/h7H,3-6H2,1-2H3,(H,12,13) |
PubChem CID | 169317 |
ChEMBL | CHEMBL157655 |
IUPHAR | 427 |
BindingDB | 82032 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 50.0 nM | PMID10496952 | PDSP,BindingDB |
Ki | 50.1187 nM | PMID10496952, PMID11266650 | IUPHAR |
Ki | 56.0 nM | PMID10496952 | PDSP,BindingDB |
Ki | 1110.0 nM | PMID12014951 | BindingDB,ChEMBL |
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