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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Neurotensin receptor type 1
Species	Rattus norvegicus (Rat)
Gene	Ntsr1
Synonym	NTS1 receptor NTRH NTR1 NTR NT-R-1 NT-1R neurotensin receptor type 1 NTSR1 neurotensin receptor 1 (high affinity) Levocabastin-insensitive neurotensin receptor High-affinity levocabastine-insensitive neurotensin receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	424
Amino acid sequence	MHLNSSVPQGTPGEPDAQPFSGPQSEMEATFLALSLSNGSGNTSESDTAGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSGDGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMVHQAAEQGRVCTVGTHNGLEHSTFNMTIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWRHRRKKRPTFSRKPNSMSSNHAFSTSATRETLY
UniProt	P20789
Protein Data Bank	3zev, 4buo, 4bv0, 4bwb, 5t04
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 3zev.
BioLiP	BL0365097, BL0267346,BL0267350, BL0267315,BL0267316, BL0267314,BL0267317, BL0267354,BL0267355, BL0267356,BL0267357, BL0365096, BL0267347,BL0267348,BL0267349,
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3027
IUPHAR	309
DrugBank	N/A

Ligand

Name	CHEMBL1790470
Molecular formula	C31H50N6O7
IUPAC name	(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2,5-diaminopentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
Molecular weight	618.776
Hydrogen bond acceptor	9
Hydrogen bond donor	7
XlogP	-2.1
Synonyms	BDBM50366311
Inchi Key	MHZLWNSONZPKGV-ROMXMSMSSA-N
Inchi ID	InChI=1S/C31H50N6O7/c1-5-19(4)26(29(41)35-24(31(43)44)16-18(2)3)36-27(39)23(17-20-10-12-21(38)13-11-20)34-28(40)25-9-7-15-37(25)30(42)22(33)8-6-14-32/h10-13,18-19,22-26,38H,5-9,14-17,32-33H2,1-4H3,(H,34,40)(H,35,41)(H,36,39)(H,43,44)/t19-,22+,23+,24+,25+,26+/m1/s1
PubChem CID	56672801
ChEMBL	CHEMBL1790470
IUPHAR	N/A
BindingDB	50366311
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	520.0 nM	, Bioorg. Med. Chem. Lett., (1993) 3:10:2055	BindingDB,ChEMBL

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