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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Type-2 angiotensin II receptor
Species	Rattus norvegicus (Rat)
Gene	Agtr2
Synonym	angiotensin II receptor, type 2 MRX88 Agtr2 AT2R AT2-R AT2 receptor angiotensin II receptor angiotensin receptor 2 Angiotensin II type-2 receptor angiotensin II type 2 receptor AT2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	363
Amino acid sequence	MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
UniProt	P35351
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL257
IUPHAR	35
DrugBank	N/A

Ligand

Name	CHEMBL316482
Molecular formula	C31H33F3N4O5S
IUPAC name	butyl N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonylcarbamate
Molecular weight	630.683
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	6.9
Synonyms	BDBM50039927 N-[[4'-[[[1-[2-(Trifluoromethyl)phenyl]-3-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol]-4-yl]methyl]-1,1'-biphenyl-2-yl]sulfonyl]carbamic acid butyl ester 2-{4-[3-butyl-5-oxo-1-(2-trifluoromethylphenyl)-4,5-dihydro-1H-1,2,4-triazol-4-ylmethyl]phenyl}-1-(N-butoxycarbonyl)benzenesulfonamide
Inchi Key	BCSNTIJHQVSLMI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C31H33F3N4O5S/c1-3-5-15-28-35-38(26-13-9-8-12-25(26)31(32,33)34)30(40)37(28)21-22-16-18-23(19-17-22)24-11-7-10-14-27(24)44(41,42)36-29(39)43-20-6-4-2/h7-14,16-19H,3-6,15,20-21H2,1-2H3,(H,36,39)
PubChem CID	9960852
ChEMBL	CHEMBL316482
IUPHAR	N/A
BindingDB	50039927
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	190.0 nM	PMID8064808	BindingDB,ChEMBL

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