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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 3
Species	Homo sapiens (Human)
Gene	HCAR3
Synonym	G-protein coupled receptor 109B Nicotinic acid receptor 2 Nic2 NIACR2 Niacin receptor 2 Low affinity nicotinic acid receptor G protein-coupled receptor 109B G-protein coupled receptor HM74B G-protein coupled receptor HM74 HCA3 receptor [ Show all ]
Disease	N/A
Length	387
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
UniProt	P49019
Protein Data Bank	N/A
GPCR-HGmod model	P49019
3D structure model	This predicted structure model is from GPCR-EXP P49019.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4421
IUPHAR	313
DrugBank	BE0000836

Ligand

Name	CHEMBL557298
Molecular formula	C20H21N3O2
IUPAC name	3-[bis(2-phenylethyl)amino]-1H-pyrazole-5-carboxylic acid
Molecular weight	335.407
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.4
Synonyms	BDBM50414500 SCHEMBL4648305
Inchi Key	MGKKDEWPHZLIHV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H21N3O2/c24-20(25)18-15-19(22-21-18)23(13-11-16-7-3-1-4-8-16)14-12-17-9-5-2-6-10-17/h1-10,15H,11-14H2,(H,21,22)(H,24,25)
PubChem CID	11992688
ChEMBL	CHEMBL557298
IUPHAR	N/A
BindingDB	50414500
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	5623.0 nM	PMID19524438	BindingDB
EC50	5623.41 nM	PMID19524438	ChEMBL

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