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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Homo sapiens (Human)
Gene	HTR2C
Synonym	Serotonin receptor 2C serotonin 1c receptor 5-HT1C 5-HT2C 5-HT-2C 5-HT2C receptor 5-HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-hydroxytryptamine receptor 1C HTR1C 5-HT-1C [ Show all ]
Disease	Pain Sleep initiation and maintenance disorders; Primary insomnia; Schizophrenia Unspecified Depression Drug abuse Generalized anxiety disorder; Major depressive disorder Major depressive disorder Metabolic disorders Psychotic disorders Mood disorder Neurological disease Obesity Obesity; Diabetes Migraine headaches Anxiety disorder Alcohol use disorders Aggressive non-hodgkin's lymphoma [ Show all ]
Length	458
Amino acid sequence	MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
UniProt	P28335
Protein Data Bank	6bqg, 6bqh
GPCR-HGmod model	P28335
3D structure model	This structure is from PDB ID 6bqg.
BioLiP	BL0404805, BL0404806
Therapeutic Target Database	T83813
ChEMBL	CHEMBL225
IUPHAR	8
DrugBank	BE0004957, BE0004881, BE0000533

Ligand

Name	imipramine
Molecular formula	C19H24N2
IUPAC name	3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
Molecular weight	280.415
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	4.8
Synonyms	Imizin (Salt/Mix) AK116463 NCGC00015563-13 Iramil BDBM50010859 NSC-169866 KBio2_001395 BSPBio_002172 Prestwick2_000072 Lopac0_000702 CHEBI:47499 SK-Pramine Declomipramine Spectrum_000915 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine DSSTox_GSID_43881 Tofranil (hydrochloride) Eupramin (Salt/Mix) Tox21_110174 5-(3-Dimethylaminopropyl)-10,f)azepine IDI1_000559 5H-Dibenz(b,f)azepine, 5-(3-(dimethylamino)propyl)-10,11-dihydro- MRF-0000592 Imipramina [Italian] 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl- NCGC00015563-04 AB00053486_16 NCGC00015563-07 Imizinum Antideprin Nelipramin Janimine BPBio1_000313 Oprea1_200908 KBio3_001392 CAS-50-49-7 Psychoforin Clomipramine HCl EP Impurity B SPBio_002204 10,11-Dihydro-5-(3-(dimethylamino)propyl)-5H-dibenz[b,f]azepine Depsonil (TN) Surplix (Salt/Mix) 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine;3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine Dyna-zina Tofranil base 5,e)azepine G-22355 W-109253 MCULE-9471074673 Imidobenzyle 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl- (9CI) N-(gamma-Dimethylaminopropyl)iminodibenzyl Imipramine [INN:BAN] ACM50497 NCGC00015563-10 InChI=1/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H AX8134492 Norfranil KB-232392 BRN 0256892 Prestwick0_000072 L000739 Censtim SBI-0050680.P004 Spectrum4_000016 2,2'-(3-Dimethylaminopropylimino)bibenzyl Dpid Tofranil 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine EINECS 200-042-1 Tofranil-PM 5-(3-(Dimethylamino)propyl)-10,f)azepine HMS2089G08 ZINC20245 5H-Dibenz(b,5-[3-(dimethylamino)propyl]-10,11-dihydro-mixed with ethyl alcohol Melipramine Imipramina 5H-Dibenz[b, 5-[3-(dimethylamino)propyl]-10,11-dihydro- NCGC00015563-02 Imiprin Imizine AKOS016010320 NCGC00024253-03 Irmin Berkomine NSC169866 KBio2_003963 C07049 Prestwick3_000072 LS-60467 SK-Pramine (Salt/Mix) 1-(3-Dimethylaminopropyl)-4,3,6,7-dibenzazepine Deprimin (TN) STL416211 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine # DSSTox_RID_80080 Tofranil (Salt/Mix) 5,6-Dihydro-N-(3-(dimethylamino)propyl)-11H-dibenz(b,e)azepine Eupramin (TN) Tox21_110174_1 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine Imavate 5H-Dibenz(b,f)azepine,5-[3-(dimethylamino)propyl]-10,11-dihydro-mixed with ethyl alcohol N-(.gamma.-Dimethylaminopropyl)iminodibenzyl AB00053486 NCGC00015563-05 AB00053486_17 NCGC00015563-08 Imizinum (Salt/Mix) Antideprin (TN) NINDS_000559 Janimine (hydrochloride) BRD-K38436528-003-05-5 Pramine KBioGR_000391 CCG-36485 Psychoforin (Salt/Mix) D06ZUK Spectrum2_000990 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine Dimipressin Surplix (TN) 3-(10,11-dihydro-5h-dibenz[b,f]azepin-5-yl)propyldimethylamine Dynaprin Tofranil(TN) 5,e]azepine G-22355 (Salt/Mix) W0042 5H-Dibenz(b, 10,11-dihydro-5-(3-(dimethylamino)propyl)- Melipramin Imipramil (TN) 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-(9CI) N-(gamma.-Dimethylaminopropyl)iminodibenzyl Imipraminum Imizin AJ-08423 NCGC00015563-11 Intalpram BCGWQEUPMDMJNV-UHFFFAOYSA-N NSC 169866 KBio1_000559 BSPBio_000283 Prestwick1_000072 Lopac-I-7379 Censtin SCHEMBL34282 (3-{2-azatricyclo[9.4.0.0;{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)dimethylamine DB00458 Spectrum5_000864 2,2'-(3-Dimethylaminopropylimino)dibenzyl DSSTox_CID_23881 Tofranil (free base) 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE Eupramin Tofraniln A 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(b,f)azepine HSDB 3100 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)propyl)- MolPort-001-783-692 Imipramina [INN-Spanish] 5H-Dibenz[b,f]azepine, 5-[3-(dimethylamino)propyl]-10,11-dihydro- NCGC00015563-03 Imizine (Salt/Mix) AN-41560 NCGC00024253-04 Irmin (TN) BIDD:GT0116 OGG85SX4E4 KBio2_006531 CAS-113-52-0 Promiben CHEMBL11 SPBio_001059 1-(3-Dimethylaminopropyl)-4,5-dihydro-2,3,6,7-dibenzazepine Deprinol (TN) Surplix 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine DTXSID1043881 Tofranil (TN) 5,6-Dihydro-N-[3-(dimethylamino)propyl]-11H-dibenz[b,e]azepine FT-0697093 UNII-OGG85SX4E4 50-49-7 Imavate (Salt/Mix) 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl- N-(3-Dimethylaminopropyl)-o-iminodibenzyl Imipramine (INN) AB00053486-15 NCGC00015563-06 AC1L1GIE NCGC00015563-09 Impramine API0006755 Norchlorimipramine Janimine (TN) BRD-K38436528-003-15-4 Prazepine KBioSS_001395 CCRIS 9173 PubChem21397 D08070 Spectrum3_000466 113-52-0 (mono-hydrochloride) DivK1c_000559 Timolet 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine Dynaprin (TN) Tofranil, base 5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine GTPL357 WLN: T C676 BN&T&J B3N1&1 5H-Dibenz(b, 5-(3-(dimethylamino)propyl)-10,11-dihydro- Melipramin (TN) Imipramin 5H-Dibenz[b, 10,11-dihydro-N,N-dimethyl- NCGC00015563-01 Imipraminum [INN-Latin] [ Show all ]
Inchi Key	BCGWQEUPMDMJNV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
PubChem CID	3696
ChEMBL	CHEMBL11
IUPHAR	357
BindingDB	50010859
DrugBank	DB00458
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
Ki	120.0 nM	PMID16712488	PDSP
Ki	150.0 nM	PMID7855217	BindingDB
Ki	160.0 nM	PMID15081025	BindingDB,ChEMBL

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