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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2B adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2b
Synonym	ADRA2L1 alpha2B-adrenoceptor alpha2B alpha2-C2 alpha-2BAR alpha-2B adrenoreceptor Alpha-2B adrenoceptor Adra-2b adrenergic receptor Adrenergic alpha2B- receptor class III ADRA2RL1 alpha-2B adrenergic receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	453
Amino acid sequence	MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
UniProt	P19328
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL266
IUPHAR	26
DrugBank	N/A

Ligand

Name	Piperoxan
Molecular formula	C14H19NO2
IUPAC name	1-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)piperidine
Molecular weight	233.311
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.6
Synonyms	PIPEROXAN1-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-piperidine Tox21_111950 1,4-BENZODIOXAN, 2-(PIPERIDINOMETHYL)- 2-Piperidinomethyl-1,4-benzodioxan AN-41783 CHEMBL31836 Fourneau 933 PDSP2_001085 Piperidine, 1-(1,4-benzodioxan-2-ylmethyl)- Piperoxano 1-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)piperidine Benodain DSSTox_GSID_46269 LS-34478 Piperoxanum [INN-Latin] 1-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-piperidine AC1L1LO6 CAS-59-39-2 F933 NCGC00160643-01 Piperoxane 1,4-Benzodioxane, 2-(piperidinomethyl)- 2-Piperidinomethyl-1,4-benzodioxane BCP19333 D04PYQ KS-00000040 Piperidine, 1-((2,3-dihydro-1,4-benzodioxin-2-yl)methyl)- Piperidine,1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]- Piperoxano [INN-Spanish] 1-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)piperidine # 59-39-2 Benodaine DSSTox_RID_81496 LYKMMUBOEFYJQG-UHFFFAOYSA-N Piperoxan [INN:BAN] SCHEMBL83631 059P392 1-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-piperidine(Piperoxan) AKOS030227988 Forneau 933 PDSP1_001101 Piperoxane [INN-French] 1-((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidine 5-20-03-00452 (Beilstein Handbook Reference) BDBM50017720 DSSTox_CID_26269 L001002 Piperidine, 1-((2,3-dihydro-1,4-benzodioxin-2-yl)methyl)- (9CI) Piperidinomethylbenzodioxan Piperoxanum 1-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)piperidine 933F BRN 0222516 DTXSID1046269 MolPort-003-823-464 [ Show all ]
Inchi Key	LYKMMUBOEFYJQG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H19NO2/c1-4-8-15(9-5-1)10-12-11-16-13-6-2-3-7-14(13)17-12/h2-3,6-7,12H,1,4-5,8-11H2
PubChem CID	6040
ChEMBL	CHEMBL31836
IUPHAR	N/A
BindingDB	50017720
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2.0 nM	PMID1656026	BindingDB

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