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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Proteinase-activated receptor 2
Species	Rattus norvegicus (Rat)
Gene	F2rl1
Synonym	coagulation factor II (thrombin) receptor-like 1 coagulation factor II receptor-like 1 GPR11 PAR-2 PAR2 Protease-activated receptor-2 Thrombin receptor-like 1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	397
Amino acid sequence	MRSLSLAWLLGGITLLAASASCNRTVNAPGPNSKGRSLIGRLDTPPPITGKGAPVEPGFSVDEFSASVLTGKLTTVFLPVIYIIVFVIGLPSNGMALWVFFFRTKKKHPAVIYMANLALADLLSVIWFPLKISYHLHGNDWTYGDALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKRANIAVGVSLAIWLLIFLVTIPLYVMRQTIYIPALNITTCHDVLPEEVLVGDMFSYFLSLAIGVFLFPALLTASAYVLMIKTLRSSAMDEHSEKKRRRAIRLIITVLSMYFICFAPSNVLLVVHYFLIKSQRQSHVYALYLVALCLSTLNSCIDPFVYYFVSKDFRDQARNALLCRSVRTVKRMQISLTSNKFSRKSSSYSSSSTSVKTSY
UniProt	Q63645
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2429706
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	H-SER-PHE-LEU-LEU-ARG-OH
Molecular formula	C30H50N8O7
IUPAC name	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Molecular weight	634.779
Hydrogen bond acceptor	9
Hydrogen bond donor	9
XlogP	-3.6
Synonyms	(2S,5S,8S,11S,14S)-14-Amino-11-benzyl-2-(3-guanidinoPropyl)-15-hydroxy-5,8-diisobutyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecan-1-oic acid HY-P1536 AKOS030525615 Ser-Phe-Leu-Leu-Arg DTXSID80649491 Thrombin Receptor Activator for Peptide 5 (TRAP-5) 141685-53-2 L-Seryl-L-phenylalanyl-L-leucyl-L-leucyl-N~5~-(diaminomethylidene)-L-ornithine BDBM85088 Ser42-Phe-Leu-Leu-Arg46 ZINC59225065 P5 CS-0044800 SFLLR-OH [ Show all ]
Inchi Key	LJYDIYITSYDTAY-LSBAASHUSA-N
Inchi ID	InChI=1S/C30H50N8O7/c1-17(2)13-22(26(41)35-21(29(44)45)11-8-12-34-30(32)33)37-27(42)23(14-18(3)4)38-28(43)24(36-25(40)20(31)16-39)15-19-9-6-5-7-10-19/h5-7,9-10,17-18,20-24,39H,8,11-16,31H2,1-4H3,(H,35,41)(H,36,40)(H,37,42)(H,38,43)(H,44,45)(H4,32,33,34)/t20-,21-,22-,23-,24-/m0/s1
PubChem CID	25254399
ChEMBL	N/A
IUPHAR	N/A
BindingDB	85088
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID10411588	BindingDB

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