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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Rattus norvegicus (Rat)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	436
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProt	P31388
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3372
IUPHAR	11
DrugBank	N/A

Ligand

Name	Chlorpromazine N-oxide
Molecular formula	C17H19ClN2OS
IUPAC name	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine oxide
Molecular weight	334.862
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	4.6
Synonyms	AC1L9DX2 Chlorpromazine oxide 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, N-oxide C10966 PDSP1_001498 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine oxide CHEMBL3220941 [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine oxide Ba 2836 CHLORPROMAZINE-N-OXIDE 1672-76-0 CAS_443037 PDSP2_001482 BDBM82476 NSC_443037 2-chloro-10-(3'-dimethyloxidoaminopropyl)phenothiazine CHEBI:3648 SCHEMBL2856438 [ Show all ]
Inchi Key	LFDFWIIFGRXCFR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19ClN2OS/c1-20(2,21)11-5-10-19-14-6-3-4-7-16(14)22-17-9-8-13(18)12-15(17)19/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID	443037
ChEMBL	N/A
IUPHAR	N/A
BindingDB	82476
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	5000.0 nM	PMID7908055	BindingDB

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