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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(1A) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd1
Synonym	D1 receptor D1A DADR dopamine D1 receptor Dopamine-1A receptor Gpcr15 [ Show all ]
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProt	P18901
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL265
IUPHAR	214
DrugBank	N/A

Ligand

Name	CHEMBL180319
Molecular formula	C15H17N3S2
IUPAC name	8-(4-methylpiperazin-1-yl)-2,4-dithia-10-azatricyclo[8.3.0.03,7]trideca-1(13),3(7),5,8,11-pentaene
Molecular weight	303.442
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.0
Synonyms	9-(4-Methyl-piperazin-1-yl)-3,4-dithia-7a-aza-cyclopenta[f]azulene BDBM50162953 SCHEMBL4915492
Inchi Key	ACRDOIMNOGBPSA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H17N3S2/c1-16-6-8-17(9-7-16)13-11-18-5-2-3-14(18)20-15-12(13)4-10-19-15/h2-5,10-11H,6-9H2,1H3
PubChem CID	11324141
ChEMBL	CHEMBL180319
IUPHAR	N/A
BindingDB	50162953
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4.91 nM	PMID15771414	BindingDB,ChEMBL

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