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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Thyrotropin receptor
Species	Homo sapiens (Human)
Gene	TSHR
Synonym	LGR3 Thyroid-stimulating hormone receptor Thyrotropin Receptor TSH receptor TSH-R
Disease	Thyroid cancer diagnosis Diagnostic test to differentiate primary and secondary hypothyroidism Thyroid cancer
Length	764
Amino acid sequence	MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHDMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL
UniProt	P16473
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T60606
ChEMBL	CHEMBL1963
IUPHAR	255
DrugBank	N/A

Ligand

Name	SR-01000838868
Molecular formula	C14H27NO6
IUPAC name	2,3-dihydroxybutanedioic acid;1,2,2,6,6-pentamethylpiperidine
Molecular weight	305.371
Hydrogen bond acceptor	7
Hydrogen bond donor	4
XlogP	None
Synonyms	HMS3373N18 KBioSS_002203 Pharmakon1600-01503383 SPBio_001430 Spectrum_001723 CCG-39333 DivK1c_006987 KBio2_002203 NCGC00016193-03 Prestwick2_000683 SPECTRUM1503383 SR-01000838868-3 2,3-dihydroxybutanedioic acid; 1,2,2,6,6-pentamethylpiperidine HMS2097I07 KBio3_001548 NSC-758448 SCHEMBL18187410 Spectrum4_001083 BSPBio_000805 HMS3714I07 MLS002153953 Prestwick0_000683 SPBio_002726 HMS1570I07 KBio2_004771 NCGC00095046-01 Prestwick3_000683 Spectrum2_001555 AC1O4WGA HMS2230D09 KBioGR_001466 NSC758448 SMR001233292 Spectrum5_001804 BSPBio_002328 CHEMBL1256139 KBio1_001931 NCGC00016193-02 Prestwick1_000683 SpecPlus_000891 SR-01000838868-2 HMS1922C04 KBio2_007339 NCGC00095046-02 Prestwick_180 Spectrum3_000744 BPBio1_000887 [ Show all ]
Inchi Key	AAFNEINEQRQMTF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H21N.C4H6O6/c1-9(2)7-6-8-10(3,4)11(9)5;5-1(3(7)8)2(6)4(9)10/h6-8H2,1-5H3;1-2,5-6H,(H,7,8)(H,9,10)
PubChem CID	6419918
ChEMBL	CHEMBL1256139
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Potency	6309.6 nM	PubChem BioAssay data set	ChEMBL

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