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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Gallus gallus (Chicken)
Gene	CHRM4
Synonym	N/A
Disease	N/A for non-human GPCRs
Length	490
Amino acid sequence	MHNLSAQPWQAKMANLTYDNVTLSNRSEVAIQPPTNYKTVELVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGVFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWILSFILWAPAILFWQFIVGKRTVHERECYIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVRRHKPESRKERKGKSLSFFKAPPVKQNNNNSPKRAVEVKEEVRNGKVDDQPSAQTEATGQQEEKETSNESSTVSMTQTTKDKPTTEILPAGQGQSPAHPRVNPTSKWSKIKIVTKQTGTESVTAIEIVPAKAGASDHNSLSNSRPANVARKFASIARSQVRKKRQMAAREKKVTRTIFAILLAFILTWTPYNVMVLINTFCETCVPETVWSIGYWLCYVNSTINPACYALCNATFKKTFKHLLMCQYRNIGTAR
UniProt	P17200
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	piperidolate
Molecular formula	C21H25NO2
IUPAC name	(1-ethylpiperidin-3-yl) 2,2-diphenylacetate
Molecular weight	323.436
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	4.4
Synonyms	AK126005 Benzeneacetic acid, alpha-phenyl-, 1-ethyl-3-piperidinyl ester (9CI) C21H25NO2 DivK1c_000112 KBio2_001863 L001277 Prestwick1_001055 1-Ethyl-3-piperidinyl diphenylacetate # Spectrum3_001524 3-Piperidinol, 1-ethyl-, diphenylacetate API0019474 BRD-A97479839-003-05-9 CHEMBL1623992 HY-B0962A KBio3_002408 N-Ethyl-3-piperidyl diphenylacetate Piperidolato SBI-0051738.P002 1087 A.N Spectrum_001383 AC1L1J2K Benzeneacetic acid, .alpha.-phenyl-, 1-ethyl-3-piperidinyl ester BSPBio_001010 Dactil KB-218859 KS-00000GXH NINDS_000112 Piperidolatum [INN-Latin] (1-ethyl-3-piperidyl) 2,2-diphenylacetate SPBio_002935 2,2-diphenylacetic acid (1-ethyl-3-piperidinyl) ester AKOS016013077 Benzeneacetic acid,.alpha.-phenyl-, 1-ethyl-3-piperidinyl ester CAS_82-98-4 DTXSID7048164 KBio2_004431 LS-11939 Piperidolate (INN) Prestwick2_001055 1-Ethyl-3-piperidyl diphenylacetate Spectrum4_000737 3-Piperidinol, 1-ethyl-, diphenylacetate (ester) AX8148240 BRD-A97479839-003-08-3 CS-4447 IDI1_000112 KBioGR_001034 NCGC00178395-01 Piperidolato [INN-Spanish] SCHEMBL249131 1087 A.N. AB00053633 ACETIC ACID, DIPHENYL-, 1-ETHYL-3-PIPERIDYL ESTER Benzeneacetic acid, alpha-phenyl-, 1-ethyl-3-piperidinyl ester BSPBio_002908 Diphenylacetic acid, 1-ethyl-3-piperidyl ester KBio1_000112 KTHVBAZBLKXIHZ-UHFFFAOYSA-N NSC_4839 Prestwick0_001055 (1-ethylpiperidin-3-yl) 2,2-diphenylacetate Spectrum2_001073 2822AC AN 1087 BPBio1_001112 CHEBI:91986 EINECS 201-449-7 KBio2_006999 MolPort-004-964-841 Piperidolate [INN:BAN] Prestwick3_001055 1-Ethylpiperidin-3-yl 2,2-diphenylacetate Spectrum5_001067 82-98-4 BDBM82378 BRN 0031110 D08382 JB 305 KBioSS_001863 NCGC00178395-02 Piperidolatum SPBio_001086 129-77-1 (hydrochloride) AB00053633_07 [ Show all ]
Inchi Key	KTHVBAZBLKXIHZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H25NO2/c1-2-22-15-9-14-19(16-22)24-21(23)20(17-10-5-3-6-11-17)18-12-7-4-8-13-18/h3-8,10-13,19-20H,2,9,14-16H2,1H3
PubChem CID	4839
ChEMBL	N/A
IUPHAR	N/A
BindingDB	82378
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	36.31 nM	PMID2250662	BindingDB

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