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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H2 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH2
Synonym	Gastric receptor I H2R HH2R
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProt	P47747
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2882
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	103851-74-7
Molecular formula	C8H8N4
IUPAC name	5-pyridin-4-yl-1H-imidazol-2-amine
Molecular weight	160.18
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	0.3
Synonyms	AKOS014774837 CHEMBL306902 SCHEMBL2768364 5-(Pyridin-4-yl)-1H-imidazol-2-amine AKOS023362375 CTK0G6761 1H-Imidazol-2-amine, 4-(4-pyridinyl)- ACMC-20m6nh DTXSID50546463 1H-Imidazol-2-amine, 5-(4-pyridinyl)- [ Show all ]
Inchi Key	AYMDMLFHNZJJEF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H8N4/c9-8-11-5-7(12-8)6-1-3-10-4-2-6/h1-5H,(H3,9,11,12)
PubChem CID	13676540
ChEMBL	CHEMBL306902
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kb	23600.0 nM	PMID2878075	ChEMBL

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