You can:
Name | Succinate receptor 1 |
---|---|
Species | Homo sapiens (Human) |
Gene | SUCNR1 |
Synonym | succinate receptor 1 succinate receptor P2Y purinoceptor 1-like P2Y purinoceptor 1 GPR91 [ Show all ] |
Disease | N/A |
Length | 334 |
Amino acid sequence | MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK |
UniProt | Q9BXA5 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9BXA5 |
3D structure model | This predicted structure model is from GPCR-EXP Q9BXA5. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2150838 |
IUPHAR | 166 |
DrugBank | BE0002258 |
Name | CHEMBL2153466 |
---|---|
Molecular formula | C31H21F6N3O |
IUPAC name | 2,2-difluoro-N-[(1S)-1-[4-[4-fluoro-3-(trifluoromethyl)phenyl]phenyl]ethyl]-2-[4-(1,8-naphthyridin-2-yl)phenyl]acetamide |
Molecular weight | 565.519 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 1 |
XlogP | 7.6 |
Synonyms | BDBM50393134 |
Inchi Key | KONYUECCRAYESO-SFHVURJKSA-N |
Inchi ID | InChI=1S/C31H21F6N3O/c1-18(19-4-6-20(7-5-19)23-10-14-26(32)25(17-23)31(35,36)37)39-29(41)30(33,34)24-12-8-21(9-13-24)27-15-11-22-3-2-16-38-28(22)40-27/h2-18H,1H3,(H,39,41)/t18-/m0/s1 |
PubChem CID | 71449508 |
ChEMBL | CHEMBL2153466 |
IUPHAR | N/A |
BindingDB | 50393134 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 19.0 nM | PMID21571530 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417