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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H2 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh2
Synonym	gastric receptor I H2 receptor H2R HH2R
Disease	N/A for non-human GPCRs
Length	358
Amino acid sequence	MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFTWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQEEKPLKLQVWSGTELTHPQGNPIR
UniProt	P25102
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4654
IUPHAR	263
DrugBank	N/A

Ligand

Name	CHEMBL3228818
Molecular formula	C14H21N3O
IUPAC name	1-[2-(dimethylamino)ethyl]-5,7-dimethyl-3,4-dihydro-1,8-naphthyridin-2-one
Molecular weight	247.342
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	1.3
Synonyms	BDBM50000956
Inchi Key	KNDFPRAPQJJNAT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H21N3O/c1-10-9-11(2)15-14-12(10)5-6-13(18)17(14)8-7-16(3)4/h9H,5-8H2,1-4H3
PubChem CID	23335380
ChEMBL	CHEMBL3228818
IUPHAR	N/A
BindingDB	50000956
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	4.8 ug.mL-1	PMID423213	ChEMBL
EC50	19000.0 nM	PMID423213	BindingDB

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