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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Proteinase-activated receptor 2
Species	Rattus norvegicus (Rat)
Gene	F2rl1
Synonym	coagulation factor II (thrombin) receptor-like 1 coagulation factor II receptor-like 1 GPR11 PAR-2 PAR2 Protease-activated receptor-2 Thrombin receptor-like 1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	397
Amino acid sequence	MRSLSLAWLLGGITLLAASASCNRTVNAPGPNSKGRSLIGRLDTPPPITGKGAPVEPGFSVDEFSASVLTGKLTTVFLPVIYIIVFVIGLPSNGMALWVFFFRTKKKHPAVIYMANLALADLLSVIWFPLKISYHLHGNDWTYGDALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKRANIAVGVSLAIWLLIFLVTIPLYVMRQTIYIPALNITTCHDVLPEEVLVGDMFSYFLSLAIGVFLFPALLTASAYVLMIKTLRSSAMDEHSEKKRRRAIRLIITVLSMYFICFAPSNVLLVVHYFLIKSQRQSHVYALYLVALCLSTLNSCIDPFVYYFVSKDFRDQARNALLCRSVRTVKRMQISLTSNKFSRKSSSYSSSSTSVKTSY
UniProt	Q63645
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2429706
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	FSLLRY-NH2
Molecular formula	C39H60N10O8
IUPAC name	(2S)-N-[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanamide
Molecular weight	796.971
Hydrogen bond acceptor	10
Hydrogen bond donor	11
XlogP	0.6
Synonyms	Phe-Ser-Leu-Leu-Arg-Tyr-NH2 (Phe1,Ser2,Tyr6)-PAR-1 (1-6) amide (human) L-Phenylalanyl-L-seryl-L-leucyl-L-leucyl-L-arginyl-L-tyrosinamide AKOS024458326 ZINC96284602 CHEMBL2431725 245329-02-6 MolPort-035-765-821 BDBM50440871 [ Show all ]
Inchi Key	KMSCNWHRNILNRJ-JNRWAQIZSA-N
Inchi ID	InChI=1S/C39H60N10O8/c1-22(2)17-30(36(55)45-28(11-8-16-44-39(42)43)35(54)46-29(33(41)52)20-25-12-14-26(51)15-13-25)47-37(56)31(18-23(3)4)48-38(57)32(21-50)49-34(53)27(40)19-24-9-6-5-7-10-24/h5-7,9-10,12-15,22-23,27-32,50-51H,8,11,16-21,40H2,1-4H3,(H2,41,52)(H,45,55)(H,46,54)(H,47,56)(H,48,57)(H,49,53)(H4,42,43,44)/t27-,28-,29-,30-,31-,32-/m0/s1
PubChem CID	73352412
ChEMBL	CHEMBL2431725
IUPHAR	N/A
BindingDB	50440871
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	50000.0 nM	PMID23895492	BindingDB,ChEMBL

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